World Journal of Emergency Medicine ›› 2024, Vol. 15 ›› Issue (4): 251-255.doi: 10.5847/wjem.j.1920-8642.2024.042
• Original Articles • Next Articles
Payush Chatta1, Brian Diep2, Jakrin Kewcharoen1, Daniel Rossie3, Cory Toomasian3, Purvi Parwani1, Dmitry Abramov1()
Received:
2023-07-20
Accepted:
2023-11-09
Online:
2024-07-09
Published:
2024-07-01
Contact:
Dmitry Abramov
E-mail:DAbramov@llu.edu
Payush Chatta, Brian Diep, Jakrin Kewcharoen, Daniel Rossie, Cory Toomasian, Purvi Parwani, Dmitry Abramov. The diagnostic yield for computed tomography pulmonary angiography in patients with anticoagulation[J]. World Journal of Emergency Medicine, 2024, 15(4): 251-255.
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URL: http://wjem.com.cn/EN/10.5847/wjem.j.1920-8642.2024.042
Table 1.
The characteristics of the included participants
Variables | No AC at presentation (n=2,394) | AC at presentation for an indication of prior VTE (n=242) | AC at presentation for other indications (n=210) | P-value |
---|---|---|---|---|
Baseline characteristics | ||||
Age, years | 58.5±17.1 | 58.7±16.9 | 68.4±14.1 | <0.001 |
Male | 1,236 (51.6%) | 103 (42.5%) | 124 (59.0%) | 0.002 |
Hypertension | 1,045 (43.6%) | 125 (51.6%) | 125 (59.5%) | <0.001 |
Diabetes mellitus | 651 (27.2%) | 78 (32.2%) | 78 (37.1%) | 0.003 |
Chronic obstructive pulmonary disease | 234 (9.8%) | 31 (12.8%) | 40 (19.0%) | <0.001 |
Chronic kidney disease | 367 (15.3%) | 49 (20.2%) | 58 (27.6%) | <0.001 |
History of heart failure | 423 (17.7%) | 79 (32.6%) | 100 (47.6%) | <0.001 |
AC use | ||||
Warfarin | 0 | 21 (8.6%) | 55 (26.20%) | <0.01 |
Apixaban | 0 | 148 (61.1%) | 110 (52.30%) | 0.19 |
Rivaroxaban | 0 | 66 (27.2%) | 43 (20.40%) | 0.14 |
Dabigatran | 0 | 7 (2.9%) | 2 (1.0%) | 0.06 |
Data at presentation | ||||
Systolic blood pressure, mmHg | 130±26 | 127+23 | 125±23 | 0.019 |
Diastolic blood pressure, mmHg | 77±16 | 77±16 | 76±15 | 0.490 |
Pulse rate, beats/min | 98±21 | 96±22 | 96±25 | 0.240 |
Oximetry, % | 96.1±4.3 | 96.3±4.4 | 96.0±3.6 | 0.650 |
NT-proBNP, pg/mL | 4,675±12,300 | 6,528±14,490 | 7,267 ±12,348 | 0.017 |
Creatinine, mg/dL | 1.36±1.71 | 1.29±1.39 | 1.54±1.42 | 2.400 |
D-dimer, μg/mL | 4.68±6.22 | 4.25±5.31 | 3.48±5.31 | 0.490 |
Elevated troponin (patients with value >99th percentile) | 447 (30.5%) | 49 (28.3%) | 46 (29.10%) | 0.810 |
INR (pts on warfarin) | - | 1.72±0.95 | 2.04±1.75 | 0.03 |
Pulmonary embolism on CTPA | 263 (9.8%) | 59 (24.3%) | 12 (5.7%) | <0.001 |
Table 2.
Multivariate analysis of association between variables and incidence of pulmonary embolism on CTPA in whole cohort
Variables | OR | 95% CI | P-value |
---|---|---|---|
Baseline characteristics and comorbidities | |||
Age | 1.01 | 0.995 - 1.03 | 0.200 |
Male | 1.22 | 0.77 - 1.91 | 0.400 |
Heart failure | 0.56 | 0.32 - 0.98 | 0.043 |
Hypertension | 1.02 | 0.62 - 1.70 | 0.940 |
Diabetes mellitus | 0.92 | 0.55 - 1.54 | 0.750 |
Chronic obstructive pulmonary disease | 1.05 | 0.54 - 2.04 | 0.950 |
Chronic kidney disease | 0.78 | 0.42 - 1.48 | 0.450 |
Anticoagulation use | 0.26 | 0.15 - 0.45 | <0.001 |
History of VTE | 98.7 | 51.6 - 188.8 | <0.001 |
Admission vitals and laboratory values | |||
Systolic blood pressure (per 10 mmHg) | 0.84 | 0.72 - 0.96 | 0.014 |
Diastolic blood pressure (per 10 mmHg) | 1.45 | 1.16 - 1.82 | 0.001 |
Oximetry (per 1%) | 1.04 | 0.99 - 1.08 | 0.104 |
NT-proBNP (per 100 pg/mL) | 1.003 | 1.000- 1.005 | 0.080 |
Creatinine | 0.94 | 0.83 - 1.07 | 0.330 |
Elevated troponin | 0.80 | 0.47 - 1.36 | 0.410 |
Table 3.
Multivariate analysis of association between variables and incidence of pulmonary embolism on CTPA in patients with anticoagulation
Variables | OR | 95% CI | P-value |
---|---|---|---|
Baseline characteristics and comorbidities | |||
Age | 0.98 | 0.95 - 1.01 | 0.190 |
Male | 1.47 | 0.64 - 3.38 | 0.360 |
Heart failure | 0.43 | 0.17 - 1.08 | 0.070 |
Hypertension | 0.89 | 0.36 - 2.21 | 0.810 |
Diabetes mellitus | 1.96 | 0.79 - 4.87 | 0.150 |
Chronic obstructive pulmonary disease | 1.26 | 0.38 - 4.23 | 0.710 |
Chronic kidney disease | 1.09 | 0.34 - 3.50 | 0.880 |
History of VTE | 3.19 | 1.21 - 8.39 | 0.020 |
Admission vitals and laboratory values | |||
Systolic blood pressure (per 10 mmHg) | 0.98 | 0.76 -1.28 | 0.890 |
Diastolic blood pressure (per 10 mmHg) | 1.05 | 0.71 - 1.57 | 0.810 |
Oximetry (per 1%) | 0.98 | 0.9 - 1.07 | 0.640 |
NT-proBNP (per 100 pg/mL) | 1.01 | 1.00 - 1.012 | 0.003 |
Creatinine | 0.96 | 0.60 - 1.55 | 0.870 |
Elevated troponin | 0.11 | 0.02 - 0.54 | 0.010 |
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