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World Journal of Emergency Medicine ›› 2012, Vol. 3 ›› Issue (4): 257-260.doi: 10.5847/wjem.j.issn.1920-8642.2012.04.003

• Review Articles • Previous Articles     Next Articles

Circulating microRNAs, novel biomarkers of acute myocardial infarction: a systemic review

Yan Chen1, Wei Yang2, Gan-nan Wang1, Jun Li2, Xiao-rong Li3, Jian Zhang3, Wei Yuan3, Dao-wu Wang3, Jin-song Zhang1(), Ke-jiang Cao3()   

  1. 1 Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    2 Department of Cardiology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 200008, China
    3 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2012-04-03 Accepted:2012-09-20 Online:2012-12-15 Published:2012-12-15
  • Contact: Jin-song Zhang,Ke-jiang Cao;


BACKGROUND: MicroRNAs (MiRNA) are a novel class of non-coding RNAs involved in the regulation of gene expression post-transcriptionally by cleavage or translational repression of their specific target miRNAs. Numerous studies have demonstrated that circulating miRNAs are stable and abundant in blood and aberrantly expressed under pathological conditions, including cardiovascular diseases. The implications of circulating miRNAs in acute myocardial infarction have recently been recognized. This review will highlight the potential role of miRNA as a novel class of biomarkers in acute myocardial infarction.

METHODS: This systemic review is based on our own work and other related reports.

RESULTS: During diseases circulating miRNAs are derived from not only circulating blood cells but also other tissues affected by ongoing diseases. These disease-related miRNAs in the blood can serve as potential biomarkers.

CONCLUSION: The circulating miRNAs can be used as novel biomarkers potentially offering more sensitive and specific tests than those currently available for diagnosis of acute myocardial infarction.

Key words: MicroRNAs, Acute myocardial infarction, Biomarkers