World Journal of Emergency Medicine ›› 2012, Vol. 3 ›› Issue (2): 135-140.doi: 10.5847/wjem.j.issn.1920-8642.2012.02.010
• Original Articles • Previous Articles Next Articles
Shi-hui Zhou, Yan-fei Sun, Gang Wang()
Received:
2011-07-28
Accepted:
2011-12-19
Online:
2012-06-15
Published:
2012-06-15
Contact:
Gang Wang
E-mail:wg5385@sohu.com
Shi-hui Zhou, Yan-fei Sun, Gang Wang. Effects of hyperbaric oxygen on intestinal mucosa apoptosis caused by ischemia-reperfusion injury in rats[J]. World Journal of Emergency Medicine, 2012, 3(2): 135-140.
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URL: http://wjem.com.cn//EN/10.5847/wjem.j.issn.1920-8642.2012.02.010
Table 1
Effects of HBO on TNF-α content, ATP activity, and optical density of caspase-3 in each group (n=10)
Parameters | I/R group | HBO-R group | HBO-P group | HBO-I group | F value |
---|---|---|---|---|---|
TNF-α (pg/g) | 1606.9±103.25* | 1536.2±136.17* | 1252.8±109.02▲* | 1021.9±91.29▲ | 58.709 |
ATP enzyme (U/mg) | 10.86±1.04* | 11.42±0.84* | 13.88±1.05▲ | 16.97±1.45▲ | 62.224 |
Optical density | 22.059±1.05* | 21.320±0.89* | 15.581±0.72▲ | 14.186±0.61▲ | 226.954 |
1 | McGhan LJ, Jaroszewski DE. The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation. Injury 2011 Jun 18 [Epub ahead of print]. |
2 |
Zhi-Yong S, Dong YL, Wang XH. Bacterial translocation and multiple system organ failure in bowel ischemia and reperfusion. J Trauma 1992; 32:148-153.
doi: 10.1097/00005373-199202000-00006 pmid: 1740793 |
3 |
Abad CL, Kumar A, Safdar N. Antimicrobial therapy of sepsis and septic shock--when are two drugs better than one?. Crit Care Clin 2011; 27:e1-27.
doi: 10.1016/j.ccc.2010.12.001 pmid: 21440195 |
4 | Shirasugi N, Wakabayashi G, Shimazu M, Oshima A, Shito M, Kawachi S. et al. Up-regulation of oxygen-derived free radical by interleukin in hepatic ischemia/reperfusion injury. Transplantation 1997; 64:1398-1403. |
5 |
Conti CR. Oxygen therapy-use and abuse in acute myocardial infarction patients. Clin Cardiol 2009; 32:480-481.
doi: 10.1002/clc.20678 pmid: 19743491 |
6 | Serra MP, Longhi P. Salvage of upper limb following a severe crushing trauma: immediate reconstruction with a free flap and subsequent hyperbaric oxygen therapy. Case Report Med 2009; 568142. Epub 2009 May 27. |
7 | Vera-Cruz P, Ferreira M, Zagalo C, dos Santos JM, Aguas AP. Structure of the rat nasal mucosa after acute and chronic hyperbaric oxygen therapy. Undersea Hyperb Med 2010; 37:125-132. |
8 | Ames JT, Federle MP. CT hypotension complex (shock bowel) is not always due to traumatic hypovolemic shock. Am J Roentgenol 2009; 192:W230-235. |
9 |
Guo W, Ge D, Wang Q, Xu S, Xue L, Lu C. et al. Diazoxide decreases ischemia-reperfusion injury in a rat model of lung transplantation. Transplant Proc 2011; 43:2510-2516.Epub 2011 Aug 4.
doi: 10.1016/j.transproceed.2011.04.015 pmid: 21911115 |
10 | Colletti LM, Green M. Lung and liver injury following hepatic ischemia/reperfusion in the rat is increased by exogenous lipopoly saccharide which also increases hepatic TNF production in vivo and in vitro. Shock 2001; 16:312-313. |
11 | Li Y, Chopp M, Jiang N, Zhang ZG, Zaloga C. Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats. Strock 1995; 26:1251. |
12 |
Saito T, Unno N, Yamamoto N, Inuzuka K, Sagara D, Suzuki M. et al. Intraperitoneal administration of hyperbarically oxygen perfluorochemical enhances preservation of intestinal mucosa against ischemia/reperfusion injury. Shock 2006; 26:620-624.
doi: 10.1097/01.shk.0000230297.93762.a8 pmid: 17117139 |
13 |
Sun Z, Wang X, Wallen R, Deng X, Du X, Hallberg E. et al. The influence of apoptosis on intestinal barrier integrity in rats. Scand J Gastroenterol 1998; 33:415-422.
doi: 10.1080/00365529850171053 pmid: 9605264 |
14 | Grossmann J, Walther K, Artinger M, Kiessling S, Scholmerich J. Apoptotic signaling during initiation of detachment-induced apoptosis ("anoikis") of primary human intestinal epithelial cells. Cell Growth Differ 2001; 12:147-155. |
15 |
Ramachandran A, Madesh M, Balasubrimanian KA. Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions. J Gastroenterol Hepatol 2000; 15:109-120.
doi: 10.1046/j.1440-1746.2000.02059.x pmid: 10735533 |
16 |
Ikeda H, Suzuki Y, Suzuki M, Koike M, Tamura J, Tong J. et al. Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut 1998; 42:530-537.
pmid: 9616316 |
17 |
Noda T, Iwakiri R, Fujimoto K, Matsuo S, Aw TY. Programmed cell death induced by ischemia-reperfusion in rat intestinal mucosa. Am J Physiol 1998; 274:G270-G276.
doi: 10.1152/ajpgi.1998.274.2.G270 pmid: 9486179 |
18 |
Decaudin D, Geley S, Hirsch T, Castedo M, Marchetti P, Macho A. et al. Bcl-2 and bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotheapentic agents. Cancer Res 1997; 57:62.
pmid: 8988042 |
19 | Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssière JL, Petit PX. et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lynphocyte death in vivo. J Exp Med 1995; 181:1662. |
20 |
Fink MP. Cytopathic hypoxia in sepsis. Acta Anaesthesiol Scand Suppl 1997; 110:87-95.
doi: 10.1111/j.1399-6576.1997.tb05514.x pmid: 9248546 |
21 |
Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Invest 1997; 100:723-735.
doi: 10.1172/JCI119585 pmid: 9239421 |
22 |
Fink MP. Cytopathic hypoxia. A concept to explain organ dysfunction in sepsis. Minerva Anestesiol 2000; 66:337-342.
pmid: 10965712 |
23 |
Crouser ED. Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion 2004; 4:729-741.
pmid: 16120428 |
24 |
Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord JM. Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 1982; 82:9-15.
pmid: 6273253 |
25 |
Sun Z, Wang X, Lasson A, Borjesson A, Leveau P, Haraldsen P. et al. Roles of platelet- activating factor, interleukin-1beta and interleukin-6 in intestinal barrier dysfunction induced by mesenteric arterial ischemia and reperfusion. J Surg Res 1999; 87:90-100.
doi: 10.1006/jsre.1999.5746 pmid: 10527709 |
26 |
Naito Y, Takagi T, Ichikawa H, Tomatsuri N, Kuroda M, Isozaki Y. et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide 2004; 10:170-177.
doi: 10.1016/j.niox.2004.04.002 pmid: 15158697 |
27 |
Gao C, Xu L, Chai W, Sun X, Zhang H, Zhang G. Amelioration of intestinal ischemia- reperfusion injury with intraluminal hyperoxygenated solution: studies on structural and functional changes of enterocyte mitochondria. J Surg Res 2005; 129:298-305.
doi: 10.1016/j.jss.2005.06.022 pmid: 16115649 |
28 |
Madesh M, Bhaskar L, Balasubramanian KA. Enterocyte viability and mitochondrial function after graded intestinal ischemia and reperfusion in rats. Mol Cell Biochem 1997; 167:81-87.
doi: 10.1023/a:1006871622049 pmid: 9059984 |
29 |
Yamada T, Taguchi T, Hirata Y, Suita S, Yagi H. The protective effect of hyperbaric oxygenation on the small intestine in ischemia-reperfusion injury. J Pediatr Surg 1995; 30:786-790.
doi: 10.1016/0022-3468(95)90748-3 pmid: 7666307 |
30 |
Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X. et al. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2011; 300:G853-61. Epub 2010 Dec 23.
doi: 10.1152/ajpgi.00459.2010 pmid: 21183660 |
31 |
Luongo C, Imperatore F, Cuzzocrea S. Effects of hyperbaric oxygen exposure on a zymosan-induced shock model. Crit Care Med 1998; 26:1972-1976.
doi: 10.1097/00003246-199812000-00022 pmid: 9875906 |
32 |
Kaelin CM, Im MJ, Myers RA, Manson PN, Hoopes JE. The effects of hyperbaric oxygen on free flaps in rats. Arch Surg 1990; 125:607-609.
doi: 10.1001/archsurg.1990.01410170053011 pmid: 2331219 |
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