Hypertensive emergency versus preeclampsia in a patient with sickle cell disease: a case report

doi:10.5847/wjem.j.1920-8642.2023.060

World Journal of Emergency Medicine ›› 2023, Vol. 14 ›› Issue (4): 329-331.doi: 10.5847/wjem.j.1920-8642.2023.060

• Case Letter • Previous Articles Next Articles

Hypertensive emergency versus preeclampsia in a patient with sickle cell disease: a case report

Jigar Patel¹, Juan A Reyes¹, Ivan Berezowski¹, Quincy K Tran²^,³(), Sarah E Frasure⁴, Ali Pourmand⁴

¹Division of Hospital Medicine, Department of Medicine, the George Washington University, Washington DC 20037, USA
²Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore 21201-1544, USA
³Program in Trauma, the R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore 21201, USA
⁴Department of Emergency Medicine, the George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA

Received:2022-09-06 Accepted:2023-02-27 Online:2023-06-30 Published:2023-07-01
Contact: Quincy K Tran E-mail:qtran@som.umaryland.edu

Abstract

Jigar Patel, Juan A Reyes, Ivan Berezowski, Quincy K Tran, Sarah E Frasure, Ali Pourmand. Hypertensive emergency versus preeclampsia in a patient with sickle cell disease: a case report[J]. World Journal of Emergency Medicine, 2023, 14(4): 329-331.

Figures/Tables 2

References 18

1	Elenga N, Adeline A, Balcaen J, Vaz T, Calvez M, Terraz A, et al. Pregnancy in sickle cell disease is a very high-risk situation: an observational study. Obstet Gynecol Int. 2016; 2016: 9069054.
2	Ataga KI, Derebail VK, Archer DR. The glomerulopathy of sickle cell disease. Am J Hematol. 2014; 89(9): 907-14. doi: 10.1002/ajh.23762 pmid: 24840607
3	Rogers DT, Molokie R. Sickle cell disease in pregnancy. Obstet Gynecol Clin North Am. 2010; 37(2): 223-37. doi: 10.1016/j.ogc.2010.02.015
4	Prophet J, Kelly K, Domingo J, Ayeni H, Mekouguem XPD, Dockery B, et al. Severe pre-eclampsia among pregnant women with sickle cell disease and HIV. Pregnancy Hypertens. 2018; 11: 87-91. doi: S2210-7789(17)30357-4 pmid: 29523281
5	Kuo K, Caughey AB. Contemporary outcomes of sickle cell disease in pregnancy. Am J Obstet Gynecol. 2016; 215(4): 505.e1-5. doi: 10.1016/j.ajog.2016.05.032
6	Boafor TK, Olayemi E, Galadanci N, Hayfron-Benjamin C, Dei-Adomakoh Y, Segbefia C, et al. Pregnancy outcomes in women with sickle-cell disease in low and high income countries: a systematic review and meta-analysis. BJOG. 2016; 123(5): 691-8. doi: 10.1111/1471-0528.13786
7	Yee MM, Jabbar SF, Osunkwo I, Clement L, Lane PA, Eckman JR, et al. Chronic kidney disease and albuminuria in children with sickle cell disease. Clin J Am Soc Nephrol. 2011; 6(11): 2628-33. doi: 10.2215/CJN.01600211
8	Nath KA, Hebbel RP. Sickle cell disease: renal manifestations and mechanisms. Nat Rev Nephrol. 2015; 11(3): 161-71. doi: 10.1038/nrneph.2015.8 pmid: 25668001
9	Darbari DS, Wang ZY, Kwak M, Hildesheim M, Nichols J, Allen D, et al. Severe painful vaso-occlusive crises and mortality in a contemporary adult sickle cell anemia cohort study. PLoS One. 2013; 8(11): e79923. doi: 10.1371/journal.pone.0079923
10	Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One. 2014; 9(7): e99489. doi: 10.1371/journal.pone.0099489
11	Elmariah H, Garrett ME, De Castro LM, Jonassaint JC, Ataga KI, Eckman JR, et al. Factors associated with survival in a contemporary adult sickle cell disease cohort. Am J Hematol. 2014; 89(5): 530-5. doi: 10.1002/ajh.23683 pmid: 24478166
12	Villers MS, Jamison MG, De Castro LM, James AH. Morbidity associated with sickle cell disease in pregnancy. Am J Obstet Gynecol. 2008; 199(2): 125. e1-5.
13	Leeman L, Fontaine P. Hypertensive disorders of pregnancy. Am Fam Physician. 2008; 78(1): 93-100. pmid: 18649616
14	Loisel DA, Billstrand C, Murray K, Patterson K, Chaiworapongsa T, Romero R, et al. The maternal HLA-G 1597ΔC null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women. Mol Hum Reprod. 2013; 19(3): 144-52. doi: 10.1093/molehr/gas041 pmid: 23002110
15	Reidy KJ, Hjorten RC, Simpson CL, Rosenberg AZ, Rosenblum SD, Kovesdy CP, et al. Fetal-not maternal-APOL1 genotype associated with risk for preeclampsia in those with African ancestry. Am J Hum Genet. 2018; 103(3): 367-76. doi: S0002-9297(18)30268-4 pmid: 30173819
16	Too GT, Hill JB. Hypertensive crisis during pregnancy and postpartum period. Semin Perinatol. 2013; 37(4): 280-7. doi: 10.1053/j.semperi.2013.04.007 pmid: 23916027
17	Samuel A, Lin C, Parviainen K, Jeyabalan A. Expectant management of preeclampsia superimposed on chronic hypertension. J Matern Fetal Neonatal Med. 2011; 24(7): 907-11. doi: 10.3109/14767058.2010.535874 pmid: 21142774
18	Yu CKH, Stasiowska E, Stephens A, Awogbade M, Davies A. Outcome of pregnancy in sickle cell disease patients attending a combined obstetric and haematology clinic. J Obstet Gynaecol. 2009; 29(6): 512-6. doi: 10.1080/01443610903003175 pmid: 19697199

Investigations (reference range)	On admission	On the 2^nd day	On discharge
Hemoglobin, mg/dL (12-16 mg/dL)	6.3	7.2	7.2
Hematocrit, % (37%-47 %)	18.0	20.7	21.2
White cell count, ×10³/μL ([4.80-10.80] ×10³/μL)	18.47	21.94	16.82
Platelet count, ×10³/μL ([130-400] ×10³/μL)	469	450	494
Potassium, mmol/L (3.5-5.0 mmol/L)	4.9	5.8	4.5
Chloride, mmol/L (95-105 mmol/L)	108	107	106
CO₂, mmol/L (22-30 mmol/L)	18	17	23
Anion gap, mmol/L (≤11 mmol/L)	13	13	8
BUN, mg/dL (7-17 mg/dL)	28	31	24
Serum creatinine, mg/dL (0.7-1.2 mg/dL)	1.7	1.4	1.1
Estimated GFR, mL/min (>90 mL/min)	43	50	73
Alkaline phosphatase, U/L (40-125 U/L)	75	63	56
AST, U/L (15-50 U/L)	43	31	38
ALT, U/L (10-45 U/L)	18	17	23
Urine total protein, mg/dL (1-15 mg/dL)	346	-	-
Urine 24 h total protein, mg (0-200 mg)	-	3,312	-
Urine creatinine, mg/dL (20-370 mg/dL)	57.9	-	-
Urine protein/creatinine ratio, mg/g	5,976	-	-
Estimated 24 h urinary protein, g	6.0	-	-
BNP, pg/mL (0.0-124.0 pg/mL)	4,990	-	-

Hypertensive emergency versus preeclampsia in a patient with sickle cell disease: a case report

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 2

References 18

Related Articles 0

Recommended Articles

Comments