Periplaneta americana extract used in patients with systemic inflammatory response syndrome

doi:10.5847/wjem.j.1920-8642.2016.01.009

World Journal of Emergency Medicine ›› 2016, Vol. 7 ›› Issue (1): 50-54.doi: 10.5847/wjem.j.1920-8642.2016.01.009

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Periplaneta americana extract used in patients with systemic inflammatory response syndrome

Hong-wei Zhang¹, Li-you Wei²(), Gang Zhao¹, Ya-jing Yang³, Shu-zheng Liu¹, Zhen-yu Zhang⁴, Zhang Jing⁴, Yan-ling Hu⁴

¹ Department of Intensive Care Unit, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China
² Department of Orthopedics, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China
³ Department of Clinical Laboratory, The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology), Tangshan 063000, China
⁴ Department of Intensive Care Unit, People's Hospital of Tangshan, Tangshan 063001, China

Received:2015-06-26 Accepted:2015-11-20 Online:2016-03-15 Published:2016-03-15
Contact: Li-you Wei E-mail:weiliyou888@163.com

Abstract

Abstract:

BACKGROUND: Periplaneta americana extract is recognized to have a positive effect on gastrointestinal mucosa. This study aimed to investigate the effects of periplaneta americana extract on immune function, nutrition status and gastrointestinal complications of early enteral nutrition patients with systemic inflammatory response syndrome (SIRS).
METHODS: Patients with SIRS were randomly divided into two groups: treatment and control groups. All patients in the two groups received conventional therapy including enteral nutrition, but periplaneta americana extract, an additional Chinese medicine, was given to the patients in the treatment group. At the beginning of treatment (0 day) and 1, 3, and 7 days after treatment, the levels of immunoglobulin (IgA), total lymphocyte count (TLC), total protein (TP) and prealbumin (PA) were respectively tested in patients' venous blood. The incidences of bloating, diarrhea, aspiration pneumonia and high blood sugar at 7 days after treatment were recorded. The mortality of the patients in 28 days was recorded.
RESULTS:At 3 and 7 days after treatment, the levels of IgA and TLC in the treatment group were higher than those in the control group (P<0.05). At 7 days after treatment, the levels of TP and PA in the treatment group were higher than those in the control group (P<0.05). The incidences of bloating and diarrhea in the treatment group were lower than those in the control group, the differences were significant (P<0.05). The mortality of treatment group was lower than that of the control group (P>0.05).
CONCLUSION: Periplaneta americana extract could reduce gastrointestinal complications and improve immune function and nutritional status in patients with systemic inflammatory response syndrome.

Key words: Periplaneta americana extract, Systemic inflammatory response syndrome, Gastrointestinal function, immune function, Nutritional status, Enteral nutrition

Hong-wei Zhang, Li-you Wei, Gang Zhao, Ya-jing Yang, Shu-zheng Liu, Zhen-yu Zhang, Zhang Jing, Yan-ling Hu. Periplaneta americana extract used in patients with systemic inflammatory response syndrome[J]. World Journal of Emergency Medicine, 2016, 7(1): 50-54.

Figures/Tables 5

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Groups	Gender	Age (mean±s, years)	APACHEII (mean±s, points)	Death [n, (%)]	Related complications [n, (%)]
Groups	Male/female	Age (mean±s, years)	APACHEII (mean±s, points)	Death [n, (%)]	Bloating	Diarrhea	Aspiration pneumonia	High blood sugar
Control	20/16	52.56±12.90	16.51±4.12	7 (19.44)	13 (36.11)	8 (22.22)	4 (11.11)	6 (16.67)
Treatment	23/11	54.32±14.56	16.92±3.82	4 (11.76)	5 (14.71)	1 (2.94)	2 (5.88)	5 (14.71)
χ²/t P-value	χ²=1.079 P=0.299	t=0.536 P=0.594	t=0.431 P=0.668	χ²=0.779 P=0.378	χ²=4.194 P=0.041	χ²=5.802 P=0.016	χ²=0.610 P=0.435	χ²=0.051 P=0.822

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Periplaneta americana extract used in patients with systemic inflammatory response syndrome

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