World Journal of Emergency Medicine ›› 2013, Vol. 4 ›› Issue (3): 223-228.doi: 10.5847/wjem.j.issn.1920-8642.2013.03.012
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Rui-ming Chang1, Li-qiang Wen1, Jian-xing Chang2, Yu-ru Fu1, Zhi-peng Jiang1, Shuang Chen2()
Received:
2013-01-22
Accepted:
2013-06-12
Online:
2013-09-15
Published:
2013-09-15
Contact:
Shuang Chen
E-mail:chensh2@mail.sysu.edu.cn
Rui-ming Chang, Li-qiang Wen, Jian-xing Chang, Yu-ru Fu, Zhi-peng Jiang, Shuang Chen. Repair of damaged intestinal mucosa in a mouse model of sepsis[J]. World Journal of Emergency Medicine, 2013, 4(3): 223-228.
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URL: http://wjem.com.cn//EN/10.5847/wjem.j.issn.1920-8642.2013.03.012
Table 1
The levels of inflammatory mediators and number of goblet cells in intestinal mucosa after CLP (mean±SD, n=7)
Groups | TNF-α (pg/mL) | IL-6 (pg/mL) | TGF-β1 (pg/mL) | Goblet cells (10 villi crypt) |
---|---|---|---|---|
Sham | 30.12±8.18 | 16.10±5.65 | 84.05±20.08 | 107.24±9.64 |
6-hour | 354.91±57.98 | 148.77±35.76 | 308.31±44.57 | 118.77±11.88 |
24-hour | 304.15±54.36 | 136.17±34.07 | 174.70±58.95# | 89.49±17.22*# |
48-hour | 370.06±82.25 | 153.04±25.03 | 137.86±54.93# | 81.83±14.42*# |
1 |
Deitch EA. Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction. Ann N Y Acad Sci 2010; 1207:E103-11.
pmid: 20961300 |
2 |
Coopersmith CM, Stromberg PE, Dunne WM, Davis CG, Amiot DM 2nd, Buchman TG, et al. Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 2002; 287:1716-1721.
pmid: 11926897 |
3 |
Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post-injury multiple organ failure: the role of the gut. Shock 2001; 15:1-10.
pmid: 11198350 |
4 |
Hubbard WJ, Choudhry M, Schwacha MG, Kerby JD, Rue LW 3rd, Bland KI, et al. Cecal ligation and puncture. Shock 2005; 24:52-57.
doi: 10.1097/01.shk.0000191414.94461.7e pmid: 16374373 |
5 |
Fernandez-Estivariz C, Gu LH, Gu L, Jonas CR, Wallace TM, Pascal RR, et al. Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding. Am J Physiol Regul Integr Comp Physiol 2003; 284:R564-573.
doi: 10.1152/ajpregu.00428.2002 |
6 |
Nadler EP, Dickinson E, Knisely A, Zhang XR, Boyle P, Beer-Stolz D, et al. Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis. J Surg Res 2000; 92:71-77.
doi: 10.1006/jsre.2000.5877 |
7 |
Yin K, Dang SC, Zhang JX. Relationship between expression of triggering receptor-1 on myeloid cells in intestinal tissue and intestinal barrier dysfunction in severe acute pancreatitis. World J Emerg Med 2011; 2:216-221.
pmid: 25215013 |
8 |
Potten CS, Kellett M, Rew DA, Roberts SA. Proliferation in human gastrointestinal epithelium using bromodeoxyuridine in vivo: data for different sites, proximity to a tumour, and polyposis coli. Gut 1992; 33:524-529.
doi: 10.1136/gut.33.4.524 pmid: 1316306 |
9 |
Nusrat A, Delp C, Madara JL. Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells. J Clin Invest 1992; 89:1501-1511.
pmid: 1569187 |
10 |
Dignass A, Lynch-Devaney K, Kindon H, Thim L, Podolsky DK. Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. J Clin Invest 1994; 94:376-383.
doi: 10.1172/JCI117332 pmid: 8040278 |
11 | Zhang C, Gao GR, Jiang HY, Lv CG, Zhang BL, Xie MS, et al. Effects of environmental hypothermia on hemodynamics and oxygen dynamics in a conscious swine model of hemorrhagic shock. World J Emerg Med 2012; 3:128-134. |
12 |
Ciacci C, Lind SE, Podolsky DK. Transforming growth factor beta regulation of migration in wounded rat intestinal epithelial monolayers. Gastroenterology 1993; 105:93-101.
pmid: 8514065 |
13 | Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature1992; 359:693-699. |
14 |
Sakuraba H, Ishiguro Y, Yamagata K, Munakata A, Nakane A. Blockade of TGF-beta accelerates mucosal destruction through epithelial cell apoptosis. Biochem Biophys Res Commun 2007; 359:406-412.
pmid: 17560553 |
15 |
Sturm A, Dignass AU. Epithelial restitution and wound healing in inflammatory bowel disease. World J Gastroenterol 2008; 14:348-353.
doi: 10.3748/wjg.14.348 pmid: 18200658 |
16 | Shi HP, Deitch EA, Da Xu Z, Lu Q, Hauser CJ. Hypertonic saline improves intestinal mucosa barrier function and lung injury after trauma-hemorrhagic shock. Shock 2002; 17:496-501. |
17 |
Zhang ZJ, Peng LB, Luo YJ, Zhou CY. Prospective experimental studies on the renal protective effect of ulinastatin after paraquat poisoning. World J Emerg Med 2012; 3:299-304.
doi: 10.5847/wjem.j.issn.1920-8642.2012.04.011 pmid: 25215081 |
18 |
Kanayama N, el Maradny E, Yamamoto N, Tokunaga N, Maehara K, Terao T. Urinary trypsin inhibitor: a new drug to treat preterm labor: a comparative study with ritodrine. Eur J Obstet Gynecol Reprod Biol 1996; 67:133-138.
pmid: 8841801 |
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