Effect of traumatic brain injury severity on intestinal barrier and gastrointestinal function

doi:10.5847/wjem.j.1920-8642.2025.010

World Journal of Emergency Medicine ›› 2025, Vol. 16 ›› Issue (1): 82-84.doi: 10.5847/wjem.j.1920-8642.2025.010

• Research Letters • Previous Articles Next Articles

Effect of traumatic brain injury severity on intestinal barrier and gastrointestinal function

Meifang Cui¹, Xiaoyu Xu², Jilu Ye¹(), Xuehua Pu¹(), Liping Ren¹

¹Intensive Care Unit, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China
²Intensive Care Unit, Nanjing Medical University, Nanjing 210000, China

Received:2024-06-16 Accepted:2024-10-26 Online:2025-01-23 Published:2025-01-01
Contact: Jilu Ye,Xuehua Pu E-mail:icuyejilu@sina.com;xuehuapu100@163.com

Abstract

Meifang Cui, Xiaoyu Xu, Jilu Ye, Xuehua Pu, Liping Ren. Effect of traumatic brain injury severity on intestinal barrier and gastrointestinal function[J]. World Journal of Emergency Medicine, 2025, 16(1): 82-84.

Figures/Tables 4

Table 1.

Table 2.

Table 3.

Figure 1.

References 10

1	Jiang JY, Gao GY, Feng JF, Mao Q, Chen LG, Yang XF, et al. Traumatic brain injury in China. Lancet Neurol. 2019; 18(3):286-95. doi: S1474-4422(18)30469-1 pmid: 30784557
2	Aramvanitch K, Khachornwattanakul K, Vichiensanth P, Jenpanitpong C, Kanchayawong P, Watcharakitpaisan S, et al. Age-appropriateness of decision for brain CT scan in elderly patients with mild traumatic brain injury. World J Emerg Med. 2023; 14(3):227-30. doi: 10.5847/wjem.j.1920-8642.2023.042 pmid: 37152541
3	Celorrio M, Abellanas MA, Rhodes J, Goodwin V, Moritz J, Vadivelu S, et al. Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis. Acta Neuropathol Commun. 2021; 9(1):40.
4	McDonald SJ, Sharkey JM, Sun MJ, Kaukas LM, Shultz SR, Turner RJ, et al. Beyond the brain: peripheral interactions after traumatic brain injury. J Neurotrauma. 2020; 37(5): 770-81.
5	Pathare N, Sushilkumar S, Haley L, Jain S, Osier NN. The impact of traumatic brain injury on microbiome composition: a systematic review. Biol Res Nurs. 2020; 22(4):495-505.
6	Gao GY, Wu X, Feng JF, Hui JY, Mao Q, Lecky F, et al. Clinical characteristics and outcomes in patients with traumatic brain injury in China: a prospective, multicentre, longitudinal, observational study. Lancet Neurol. 2020; 19(8): 670-7. doi: S1474-4422(20)30182-4 pmid: 32702336
7	Pan PF, Song YL, Du XX, Bai LL, Hua XL, Xiao YW, et al. Intestinal barrier dysfunction following traumatic brain injury. Neurol Sci. 2019; 40(6): 1105-10. doi: 10.1007/s10072-019-03739-0 pmid: 30771023
8	Fu WJ, Shi NX, Wan YH, Mei F, Qiu BH, Bao Y, et al. Risk factors of acute gastrointestinal failure in critically ill patients with traumatic brain injury. J Craniofac Surg. 2020 ;31(2): e176-e179.
9	Krishnamoorthy V, Komisarow JM, Laskowitz DT, Vavilala MS. Multiorgan dysfunction after severe traumatic brain injury: epidemiology, mechanisms, and clinical management. Chest. 2021; 160(3): 956-64. doi: 10.1016/j.chest.2021.01.016 pmid: 33460623
10	Tang AL, Li Y, Sun LC, Liu XY, Gao N, Yan ST, et al. Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway. World J Emerg Med. 2024; 15(3):206-13.

Parameters	Mild TBI (n=35)	Moderate TBI (n=33)	Severe TBI (n=33)
D-lactic acid, mg/L
Day 1	7.35±1.04	8.76±1.83^*	13.63±2.70^#
Day 3	8.17±1.35	9.90±1.74^#	16.79±3.40^#
Day 7	6.61±1.09	7.65±1.48^*	12.56±2.24^#
DAO, U/L
Day 1	6.79±1.71	7.75±1.92	9.95±2.27^#
Day 3	11.58±2.28	14.58±3.52^#	21.44±5.15^#
Day 7	4.52±1.69	6.82±2.03^#	9.22±2.36^#
Endotoxin, EU/mL
Day 1	0.15±0.12	0.26±0.12^*	0.38±0.14^#
Day 3	0.44±0.15	0.68±0.15^#	0.85±0.17^#
Day 7	0.14±0.11	0.23±0.10^#	0.35±0.13^#

Parameters	GCS
Parameters	r	P-value
D-lactic acid, mg/L
Day 1	-0.9274	<0.0001
Day 3	-0.8990	<0.0001
Day 7	-0.8680	<0.0001
DAO, U/L
Day 1	-0.7481	<0.0001
Day 3	-0.8326	<0.0001
Day 7	-0.7992	<0.0001
Endotoxin, EU/mL
Day 1	-0.7737	<0.0001
Day 3	-0.8313	<0.0001
Day 7	-0.7651	<0.0001

Time	Occurrence of acute gastrointestinal injury			χ²	P-value
Time	Mild group (n=35) Moderate group (n=33) Severe group (n=33)			χ²	P-value
Day 1				113.32	<0.001
Yes	14 (40.0)	10 (30.3)	23 (69.7)
No	21 (60.0)	23 (69.7)	10 (30.3)
Day 3				69.45	<0.001
Yes	17 (48.6)	24 (72.7)	31 (93.9)
No	18 (51.4)	8 (24.2)	2 (6.1)
Day 7				119.81	<0.001
Yes	10 (28.6)	15 (45.5)	26 (78.8)
No	25 (71.4)	18 (54.5)	7 (21.2)

Effect of traumatic brain injury severity on intestinal barrier and gastrointestinal function

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 4

References 10

Related Articles 0

Recommended Articles

Comments