Early prediction cardiac arrest in intensive care units: the value of laboratory indicator trends

doi:10.5847/wjem.j.1920-8642.2025.003

World Journal of Emergency Medicine ›› 2025, Vol. 16 ›› Issue (1): 67-70.doi: 10.5847/wjem.j.1920-8642.2025.003

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Early prediction cardiac arrest in intensive care units: the value of laboratory indicator trends

Wentao Sang¹^,²^,³^,⁴^,⁵, Jiaxin Ma¹^,²^,³^,⁴^,⁵, Xuan Zhang¹^,²^,³^,⁴^,⁵, Shuo Wu¹^,²^,³^,⁴^,⁵, Chang Pan¹^,²^,³^,⁴^,⁵, Jiaqi Zheng¹^,²^,³^,⁴^,⁵, Wen Zheng¹^,²^,³^,⁴^,⁵, Qiuhuan Yuan¹^,³^,⁴^,⁵, Jian Zhang¹^,²^,³^,⁴^,⁵, Jingjing Ma¹^,²^,³^,⁴^,⁵(), Feng Xu¹^,²^,³^,⁴^,⁵()

¹Department of Emergency Medicine, Qilu Hospital, Shandong University, Jinan 250012, China
²Chest Pain Center, Qilu Hospital, Shandong University, Jinan 250012, China
³Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital, Shandong University, Jinan 250012, China
⁴Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital, Shandong University, Jinan 250012, China
⁵Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences
⁶the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine
⁷Qilu Hospital, Shandong University, Jinan 250012, China

Received:2024-06-18 Accepted:2024-10-20 Online:2025-01-23 Published:2025-01-01
Contact: Jingjing Ma,Feng Xu E-mail:mj_365@163.com;xufengsdu@126.com

Abstract

Wentao Sang, Jiaxin Ma, Xuan Zhang, Shuo Wu, Chang Pan, Jiaqi Zheng, Wen Zheng, Qiuhuan Yuan, Jian Zhang, Jingjing Ma, Feng Xu. Early prediction cardiac arrest in intensive care units: the value of laboratory indicator trends[J]. World Journal of Emergency Medicine, 2025, 16(1): 67-70.

Figures/Tables 3

Figure 1.

Table 1.

Table 2.

References 14

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Parameters	Overall (n=1,173)	ICU-CA patients (n=391)	Controls (n=782)	P-value
Age, years, median (IQR)	63 (50, 73)	64 (52, 74)	62 (48, 73)	0.023
Sex (male), n (%)	832 (70.9)	277 (70.8)	555 (71.0)	0.964
CAD, n (%)	411 (35.0)	155 (39.6)	256 (32.7)	0.019
COPD, n (%)	79 (6.7)	29 (7.4)	50 (6.4)	0.510
DM, n (%)	265 (22.6)	101 (25.8)	164 (21.0)	0.061
Stroke, n (%)	248 (21.1)	78 (19.9)	170 (21.7)	0.479
Malignancy, n (%)	128 (10.9)	48 (12.3)	80 (10.2)	0.289
Hypertension, n (%)	593 (50.6)	186 (47.6)	407 (52.0)	0.148
Hyperlipidemia, n (%)	148 (12.6)	51 (13.0)	97 (12.4)	0.756
Current smoking, n (%)	493 (42.0)	168 (43.0)	325 (41.6)	0.645
ICU, n (%)				1.000
General ICU	648 (55.2)	214 (54.7)	434 (55.5)
Emergency ICU	53 (4.5)	18 (4.6)	35 (4.5)
Cardiac ICU	60 (5.1)	20 (5.1)	40 (5.1)
Respiratory ICU	89 (7.6)	30 (7.7)	59 (7.5)
Neurosurgical ICU	159 (1.3)	5 (1.3)	10 (1.3)
Cardiac surgical ICU	308 (26.3)	104 (26.6)	204 (26.1)

Parameters	Coefficient	SE	OR (95% CI)	P-value
Intercept	-2.888	1.059		0.006
Na⁺, mmol/L
<135	-0.018	0.249	0.982 (0.602-1.601)	0.941
135-145	Ref	-	-	-
>145	0.740	0.231	2.095 (1.331-3.297)	0.001
K⁺	0.338	0.130	1.403 (1.087-1.810)	0.009
Ca²⁺	-0.754	0.596	0.470 (0.146-1.513)	0.206
HGB, g/L	-0.009	0.004	0.991 (0.983-0.999)	0.026
Lac ^a, Log	1.095	0.134	2.990 (2.298-3.891)	<0.001
pH ^b
<7.35	0.253	0.249	1.288 (0.790-2.099)	0.310
7.35-7.45	Ref	-	-	-
>7.45	-0.043	0.192	0.958 (0.658-1.396)	0.823
Time ^c	-0.080	0.054	0.923 (0.831-1.026)	0.137
Age	0.014	0.007	1.014 (0.999-1.029)	0.070
Sex, male	0.024	0.254	1.024 (0.622-1.687)	0.925
CAD	0.548	0.275	1.731 (1.008-2.970)	0.047
DM	0.292	0.291	1.339 (0.757-2.368)	0.316
Malignancy	0.266	0.369	1.304 (0.632-2.691)	0.472
Hypertension	-0.480	0.249	0.619 (0.380-1.010)	0.055
Stroke	-0.342	0.306	0.710 (0.390-1.295)	0.264

Early prediction cardiac arrest in intensive care units: the value of laboratory indicator trends

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