Neurotoxicity due to dimethylamine borane poisoning via skin absorption: a case report

doi:10.5847/wjem.j.1920-8642.2022.096

World Journal of Emergency Medicine ›› 2022, Vol. 13 ›› Issue (6): 500-503.doi: 10.5847/wjem.j.1920-8642.2022.096

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Neurotoxicity due to dimethylamine borane poisoning via skin absorption: a case report

Guang-cai Yu¹^,², Ya-qian Li¹, Tian-zi Jian¹, Bao-tian Kan¹^,³, Si-qi Cui¹^,³, Ping Han¹(), Xiang-dong Jian¹^,²^,⁴()

¹Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
²Shandong University of Traditional Chinese Medicine, Jinan 250012, China
³Department of Geriatric Medicine, Qilu Hospital of Shandong University, School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
⁴School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China

Received:2022-02-16 Accepted:2022-07-21 Online:2022-08-17 Published:2022-11-01
Contact: Ping Han,Xiang-dong Jian E-mail:hanpingsdjn@126.com;jianxiangdongvip@vip.163.com

Abstract

Guang-cai Yu, Ya-qian Li, Tian-zi Jian, Bao-tian Kan, Si-qi Cui, Ping Han, Xiang-dong Jian. Neurotoxicity due to dimethylamine borane poisoning via skin absorption: a case report[J]. World Journal of Emergency Medicine, 2022, 13(6): 500-503.

Figures/Tables 3

Figure 1.

Figure 2.

Table 1.

References 12

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3	Roselló-Merino M, López-Serrano J, Conejero S. Dehydrocoupling reactions of dimethylamine-borane by Pt(II) complexes: a new mechanism involving deprotonation of boronium cations. J Am Chem Soc. 2013; 135(30): 10910-3. doi: 10.1021/ja404655v pmid: 23822667
4	Ballantyne B, Dodd DE, Myers RC, Nachreiner DJ, Pritts IM. The acute toxicity of tris(dimethylamino)silane. Toxicol Ind Health. 1989; 5(1): 45-54. pmid: 2718185
5	Huang CC, Kuo HC, Tsan YT, Hung DZ. Correspondence: dimethylamine borane neurotoxicity and authors’ response. Environ Health Perspect. 2006; 114(5): a274.
6	Kuo HC, Huang CC, Chu CC, Chu NS. Axonal polyneuropathy after acute dimethylamine borane intoxication. Arch Neurol. 2006; 63(7): 1009-12. doi: 10.1001/archneur.63.7.1009
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12	Mathews JM, Watson SL, Patel PR, Black SR, Hong Y, Levine KE, et al. Metabolism and disposition of [14C] dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application. Xenobiotica. 2014; 44(1): 36-47. doi: 10.3109/00498254.2013.800662 pmid: 23786350

Nerves	Content inspection	2021-08-12 [R/L]	2021-08-24 [R/L]	2021-08-30 [R/L]	2021-10-08 [R/L]	2021-12-21 [R/L]	2022-07-18 [R/L]
Motor nerve conduction
Medianus	Lat, ms	-	7.0 (L)	8.2/7.2	8.3 (R)	7.5 (R)	7.2 (L)
	Amp, mV	-	5.6 (L)	4.2/3.7	4.2 (R)	5.8 (R)	6.8 (L)
	NCV, m/s	-	60.5 (L)	52.2/63.2	51.1 (R)	54.9 (R)	57.5 (L)
Ulnaris	Lat, ms	-	6.3 (L)	6.1/6.1	7.6 (R)	6.0 (R)	-
	Amp, mV	-	5.9 (L)	4.3/5.2	5.2 (R)	7.4 (R)	-
	NCV, m/s	-	64.9 (L)	54.1/65.2	53.3 (R)	62.1 (R)	-
Peroneus	Lat, ms	10.5/11.8	13.2/14.0	13.4/13.9	15.2/4.6	13.1/2.9	12.5/14.9
	Amp, mV	3.3/0.8	0.8/0.2	0.7/0.2	0.5/0.6	0.3/1.3	1.5/0.7
	NCV, m/s	50.0/43.0	40.7/38.2	44.2/37.4	33.2/N	39.1/N	43.4/38.8
Tibialis	Lat, ms	13.9/13.5	17.7/15.9	17.9/16.0	20.5/19.0	15.6/15.3	14.2/13.0
	Amp, mV	9.5/10.9	6.4/6.9	3.0/4.1	1.7/1.5	1.4/1.7	4.3/3.2
	NCV, m/s	44.8/44.2	41.2/39.9	35.7/41.2	36.8/38.2	43.8/44.1	43.8/45.1
Sensory nerve conduction
Medianus	Lat, ms	-	2.4 (L)	2.5/2.4	2.5 (R)	2.6 (R)	2.6 (L)
	Amp, mV	-	21 (L)	24/21	27 (R)	22 (R)	21 (L)
	NCV, m/s	-	64.6 (L)	54.0/56.2	56 (R)	59.6	59.6 (L)
Ulnaris	Lat, ms	-	2.2 (L)	2.3/2.2	2.5 (R)	2.1 (R)	-
	Amp, mV	-	24 (L)	24/25	30 (R)	20 (R)	-
	NCV, m/s	-	63.6 (L)	47.8/59.1	50 (R)	57.1 (R)	-
Peroneus	Lat, ms	2.9/2.6	3.2/2.8	3.8/3.7	3.3/3.1	3.6/3.1	2.1/2.4
	Amp, mV	9.4/16	9.4/8.1	5.0/14	18/12	5.5/8.3	11/15
	NCV, m/s	51.7/48.1	42.2/44.6	39.5/37.8	39.4/41.9	48.6/48.4	50.0/45.8
Suralis	Lat, ms	2.4/2.8	3.3/3.5	3.4/3.3	3.7/3.5	3.3/3.0	2.0/2.4
	Amp, mV	14/17	10/11	16/10	13/11	8.9/7.0	8.3/7.0
	NCV, m/s	58.3/53.6	45.5/40.0	41.2/37.9	41.9/40.0	48.5/51.7	52.5/45.8
H-reflex
Tibialis	H-lat, ms	33/34.7	35/35.3	36.3/35.5	34.3/36.7	32.8/34.0	31.2/31.5
Tibialis	H-amp, mV	0.2/0.6	0.4/1.8	0.1/0	2.5/1.6	2.5/2.2	3.9/3.1

Neurotoxicity due to dimethylamine borane poisoning via skin absorption: a case report

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