Treatment of vitamin K-dependent coagulation factor deficiency and subarachnoid hemorrhage

World Journal of Emergency Medicine ›› 2011, Vol. 2 ›› Issue (1): 73-76.

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Treatment of vitamin K-dependent coagulation factor deficiency and subarachnoid hemorrhage

Hai-fei Chen, Tian-qin Wu, Ling-juan Jin, Jie-qing Tang, Jing-jing Zhu, Ying-chao Ge, Zheng-yang Li, Hong-shi Shen, Long-mei Qin, Zi-qiang Yu, Zhao-yue Wang()

Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China

Received:2010-09-08 Accepted:2010-12-11 Online:2011-03-15 Published:2011-03-15
Contact: Zhao-yue Wang E-mail:chhf1224@163.com

Abstract

Abstract:

BACKGROUND: In adults, vitamin K-dependent coagulation factor deficiency (VKCFD) increases in the recent years. We treated a VKCFD patient with subarachnoid hemorrhage, with favorable outcomes.
METHODS: A 19-year-old male student with VKCFD was treated at our hospital. The initial treatment was injection of a large dose of vitamin K and fresh plasma, and then with oral high dose of vitamin K4.
RESULTS: At 4 weeks after admission, the focus of hemorrhage subsided, neurological examination was normal, and the patient was discharged.
CONCLUSIONS: VKCFD is rare and its diagnosis should be based on the history of the patient and the results of laboratory examinations. A large dose of vitamin K is the first choice of treatment.

Key words: Vitamin K-dependent coagulation factor deficiency, Subarachnoid hemorrhage, Diagnosis

Hai-fei Chen, Tian-qin Wu, Ling-juan Jin, Jie-qing Tang, Jing-jing Zhu, Ying-chao Ge, Zheng-yang Li, Hong-shi Shen, Long-mei Qin, Zi-qiang Yu, Zhao-yue Wang. Treatment of vitamin K-dependent coagulation factor deficiency and subarachnoid hemorrhage[J]. World Journal of Emergency Medicine, 2011, 2(1): 73-76.

Figures/Tables 3

Figure 1.

Figure 2.

Table 1

References 8

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Date	ViK4 (mg/d)	FII (%)	FVII (%)	FIX (%)	FX( %)	VWF	APTT (s)	PT (s)	INR	TT (s)	Fig (g/L)	AT-III
2009/12/18	80						145.8	120.0		20.3	4.47	193
2009/12/21	80	81	34	37	63	148	41.6	17.4	1.39	16.3	4.41	127
2009/12/24	80	83	17	60	44		42.1	22.5	1.90	14.0	6.22	127
2009/12/25	120
2009/12/28	120	94	22	28	44		44.3	20.0	1.64	17.3	5.88	115
2010/1/04	120	72	31	97	45		38.9	18.8	1.53	16.9	4.16	93
2010/1/11	120	78	28	50	52		44.2	19.0	1.55	16.0	4.76	120
2010/1/12	180
2010/1/18	180	84	35	43	54		38.7	17.2	1.37	15.4	3.72	113
2010/1/20	240
2010/1/22	240	86	70	96	84		41.0	15.5	1.21	16.4	3.75	111
2010/1/26	240	89	57	90	66		40.3	16.0	1.25	15.6	3.86	126
2010/1/28	60^#
2010/3/01	60^※	17	3	4	17		74.0	55.3	5.97	16.4	3.43	96
2010/3/03	100						82.2	57.2	6.23	16.0	3.09	81
2010/3/08	200	9	9	4	19		96.2	43.7	4.43	17.5	3.65	89
2010/3/15	200						47.6	30.0			4.30
2010/3/20	200						45.6	27.7		14.1	3.70
2010/3/30	240						47.8	14.8		14.6	3.98
2010/4/03	240	92	86	76	123		34.6	13.7	1.25	16.3	3.76	93
2010/6/03	200	85	92	89	114		33.8	15.3	1.24	15.2	3.81	87
2010/9/03	160	94	104	87	117		35.6	14.8	1.32	16.4	3.35	97

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Treatment of vitamin K-dependent coagulation factor deficiency and subarachnoid hemorrhage

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