World Journal of Emergency Medicine ›› 2011, Vol. 2 ›› Issue (3): 210-215.doi: 10.5847/wjem.j.1920-8642.2011.03.010
• Original Article • Previous Articles Next Articles
Hai-bin Ni, Zheng Zhang(), Hai-dong Qin
Received:
2011-03-21
Accepted:
2011-08-03
Online:
2011-09-15
Published:
2011-09-15
Contact:
Zheng Zhang
E-mail:qsp1999@126.com
Hai-bin Ni, Zheng Zhang, Hai-dong Qin. Protective effect of glutamine in critical patients with acute liver injury[J]. World Journal of Emergency Medicine, 2011, 2(3): 210-215.
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URL: http://wjem.com.cn//EN/10.5847/wjem.j.1920-8642.2011.03.010
Table 1
Baseline characteristics about patients in the two groups at admission
Variables | Control group (n=22) | Gln group (n=22) | p |
---|---|---|---|
Age (yr) | 49.5 (22-68) | 50.4 (24-67) | 0.39 |
Male (%) | 15 (68.2) | 14 (63.6) | 0.61 |
APACHE II score | 20.7 (11-26) | 20.5 (10-28) | 0.19 |
ALT (U/L) | 158 (135-179) | 156 (145-174) | 0.55 |
AST (U/L) | 105 (93-112) | 109 (89-114) | 0.59 |
TbiL (μmol/L) | 65.4 (61-72) | 67.1 (58-71) | 0.42 |
Classification of diseases | |||
Severe pneumonia (%) | 8 (36) | 9 (41) | 0.94 |
Severe sepsis (%) | 6 (27) | 5 (23) | 0.89 |
Multi-trauma (%) | 3 (14) | 3 (14) | 0.77 |
ICH (%) | 2 (9) | 3 (14) | 0.95 |
COPD (%) | 3 (14) | 2 (9) | 0.81 |
Table 2
Change of patients' parameters between the two groups before and after the treatment
Variables | Control group | Gln group | |||
---|---|---|---|---|---|
Before treatment | After treatment | Before treatment | After treatment | ||
Gln (μmol/L) | 322.6 (247-397) | 351.6 (332-411) | 313.3 (281-405) | 466.4*# (386-566) | |
HSP70 (μg/L) | 0.435 (0.136-0.689) | 0.528 (0.144-0.751) | 0.457 (0.133-0.714) | 1.959*# (1.255-2.898) | |
ALT (U/L) | 158 (135-179) | 85 (75-85) | 156 (145-174) | 63 (45-59)*# | |
AST (U/L) | 105 (93-112) | 62±3.9 (58-65) | 109 (89-114) | 45 (40-49) *# | |
TbiL (μmol/L) | 65.4 (61-72) | 33.6(30-38) | 67.1 (58-71) | 29.5 (25-31)*# | |
TNF-α (pg/L) | 348.9 (289-438) | 125 (89-155) | 364 (278-455) | 70 (50-81) *# | |
IL-6 (pg/L) | 120 (85-166) | 40 (28-52) | 115 (78-154) | 25 (21-32) *# | |
CD3 (%) | 49.4±6.5 | 50.2±5.6 | 49.2±6.6 | 53.4±6.5*# | |
CD4 (%) | 28.5±6.7 | 29.5±7.4 | 28.4±6.5 | 32.7±6.8*# | |
CD8 (%) | 20.2±6.7 | 22.3±6.5 | 20.7±6.9 | 21.6±5.9 | |
CD4/CD8 | 1.41±0.47 | 1.32±0.52 | 1.36±0.57 | 1.51±0.42*# |
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