Artificial liver support system in treatment of liver failure after acute poisoning

doi:10.5847/wjem.j.1920-8642.2011.04.007

Abstract

Abstract:

BACKGROUND: Acute poisoning (AP) may cause failure of the liver and kidney, and even death. This study aimed to investigate the efficacy of artificial liver support system (ALSS) on the treatment of liver failure after acute poisoning.
METHODS: A total of 31 patients with liver failure caused by AP were admitted to emergency ICU, central ICU, and Department of Gastroenterology from 2005 to 2009 in Zhongshan Hospital Affiliated to Xiamen University, China. Among them, 13 patients served as a treatment group, and used ALSS in addition to detoxification treatment and protective treatment of liver function, and the other 18 patients served as a control group receiving detoxification treatment and protective treatment of liver function.
RESULTS: In the treatment group, 10 patients (76.9%) were cured or improved, 2 died, and 1 was discharged against advice. In the 18 patients in the control group, 7 (38.9%) were cured or improved, 3 died, and 8 were discharged against advice. There was a significant difference in the rates of improvement between the two groups (P<0.05).
CONCLUSION: ALSS is a safe and effective clinical method for the treatment of acute toxic liver failure.

Key words: Toxicity, Liver failure, Artificial liver support system

Li-gang Chen, Bayasi Guleng, Jian-lin Ren, Jian-min Chen, Lin Wang. Artificial liver support system in treatment of liver failure after acute poisoning[J]. World Journal of Emergency Medicine, 2011, 2(4): 283-286.

Figures/Tables 2

References 14

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Groups	AST (U/L)	ALT (U/L)	PT (s)	ALB (g/L)	TBIL (μmol/L)	NH3 (μmol/L)
Control group
Before treatment	843.7±263.4	1032.5±389.7	18.7±3.9	30.4±5.0	332.7±110.8	284.9±92.7
After treatment	273.4±97.3	337.4±108.1^*	15.4±1.1^*	31.4±6.1	296.7±104.3	276.2±84.5
Treated group
Before treatment	875.8±259.4	1024.7±397.2	18.5±4.2	29.7±4.7	328.4±113.1	274.6±87.4
After treatment	145.2±45.6^**Δ	133.8±34.9^**Δ	15.6±1.4^*	31.2±5.4	175.6±87.5^*Δ	115.3±37.8^*ΔΔ
Groups	WBC (*10⁹/L)	PLT (*10⁹/L)	K⁺(mmol/L)	Na⁺(mmol/L)	BUN (mmol/L)	Cr (μmol/L)
Control group
Before treatment	12.3±2.2	173.0±24.6	4.18±0.81	134.9±7.6	11.8±2.01	173.0±24.6
After treatment	10.5±1.6	154.8±19.8	4.02±0.58	135.7±6.4	9.56±1.12	154.8±19.8
Treated group
Before treatment	12.1±2.3	163.4±21.3	4.23±0.85	137.5±8.8	12.4±1.96	163.4±21.3
After treatment	10.8±1.5	78.5±8.4^*ΔΔ	4.12±0.79	136.5±6.3	6.6±0.71^**ΔΔ	78.5±8.4^*ΔΔ

Variables	Control group	Treatment group
Improvement in the cure rate	7 (38.9%)	10 (76.9%)
Against advice discharge	8	10
Mortality	3	11
Total	18	13

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