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处方药物滥用-阿片类药物相关死亡的危险因素是什么?
原作者: Fermin Barrueto, 陈都翻 发布日期:2014-04-14

处方药物滥用 – 阿片类药物相关死亡的危险因素是什么
翻译:陈都 校对:肖锋

Title: Prescription Drug Abuse - What are Risk Factors for OD Death?
题目:处方药物滥用 – 阿片类药物相关死亡的危险因素是什么
Author 作者: Fermin Barrueto

What are characteristics that increase the chance a patient is at risk for opioid-related death? A recent JAMA article begins to tackle this very issues. Baumblatt et al. found the following:
增加患者阿片类药物相关死亡的特征有哪些?近期在JAMA上发表的一篇文章研究了这个问题。Baumblatt等发现:
1) Patient with 4 or more prescribers had adjusted odds ratio 6.5 for opioid-related death
有四个或者四个以上开处方医生的患者,其阿片类药物相关死亡调整过的优势比为6.5。
2) Patient with 4 or more pharmacies where they get their prescriptions aOR - 6.0
从四个或者四个以上药房取药的患者,其阿片类药物相关死亡调整过的优势比为6.0。
3) Patient with more than 100 mg of morphine equivalents mean per day aOR - 11.2
每天服用相当于100毫克以上吗啡的患者,其阿片类药物相关死亡调整过的优势比为11.2。
With the new Maryland Prescription Drug Monitoring program (PDMP)  we can start looking at a patient's prescription drug use pattern. The recent JAMA article can help you identify patients at high risk to die an opioid-related death. Use the PDMP and be wary if a patient has more than 4 prescribers or pharmacies or has >100mg of morphine equivalents per day.
通过马里兰处方药监控系统(PDMP),我们开始监控患者处方药的使用习惯。最近JAMA上的文章可以帮助识别阿片类药物相关死亡的高危患者。使用PDMP帮助我们对有四个以上开处方的医生或者四个以上的取药药店,或每日超过100毫克吗啡的患者引起警觉。
References 参考文献
High-Risk Use by Patients Prescribed Opioids for Pain and Its Role in Overdose Deaths.
Baumblatt JA, Wiedeman C, Dunn JR, Schaffner W, Paulozzi LJ, Jones TF.
JAMA Intern Med. 2014 Mar 3. doi: 10.1001/jamainternmed.2013.12711.