ICU-acquired weakness in critically ill patients at risk of malnutrition: risk factors, biomarkers, and early enteral nutrition impact

Qingliu Zheng, Changyun Liu, Lingying Le, Qiqi Wu, Zhihong Xu, Jiyan Lin, Qiuyun Chen

Table 1. Univariate logistic regression analysis of risk factors for different outcomes

Parameters ICU-AW (n=75) Non-ICU-AW (n=105) OR 95% CI P-value Male, n (%) 45 (60.0) 68 (64.8) 0.336 0.179-0.628 0.001 Age, years, median (IQR) 74.0 (67.0-84.0) 73.0 (65.5-82.0) 1.085 1.049-1.123 <0.001 BMI, kg/m2, median (IQR) 19.6 (17.8-21.6) 21.0 (19.4-20.8) 0.716 0.622-0.824 <0.001 Underlying disease, n (%) Hypertension 36 (48.0) 50 (47.6) 0.960 0.544-1.782 0.985 Diabetes 26 (34.7) 24 (22.9) 0.083 0.246-3.185 0.558 Malignant tumor 17 (22.7) 11 (10.5) 2.505 1.097-5.721 0.029 MV, n (%) 18 (24.0) 13 (12.4) 2.235 1.018-4.905 0.048 TRF, g/L, median (IQR) 2.5 (2.3-3.3) 2.6 (2.1-2.9) 0.545 0.326-0.910 0.020 PAB, mg/L, median (IQR) 110.0 (89.0-160.0) 124.0 (98.0-180.0) 0.998 0.993-1.003 0.419 ALB, g/L, median (IQR) 35.2 (33.2-37.5) 33.8 (32.5-32.7) 1.167 1.047-1.300 0.005 CRP, mg/L, median (IQR) 77.6 (65.3-89.8) 69.3 (63.3-80.0) 1.007 1.996-1.019 0.205 IL-6, pg/mL, median (IQR) 63.2 (42.3-78.3) 58.3 (36.1-66.9) 1.016 1.002-1.030 0.022 BUN, mmol/L, median (IQR) 11.8 (10.5-12.8) 9.1 (7.8-10.2) 2.548 1.903-3.411 <0.001 Cr, μmol/L, median (IQR) 124.0 (105.0-198.0) 99.0 (87.0-111.0) 1.016 1.009-1.023 <0.001 EEN, n (%) 32 (42.7) 64 (61.9) 0.477 0.261-0.871 0.016