Effects of PEAR1 gene polymorphism on big endothelin-1 levels in Chinese patients with acute myocardial infarction after percutaneous coronary intervention

Yi Yao, Na Xu, Xiaofang Tang, Ce Zhang, Sida Jia, Jingjing Xu, Ying Song, Xueyan Zhao, Runlin Gao, Jinqing Yuan

Table 1. Effects of different PEAR1 SNPs on big ET-1 levels

PEAR1 SNP Genotypes (n) Big ET-1 (pmol/L, median [interquartile]) OR (95% confidence intervals) P-value rs11264579 CC (158) 0.34 (0.23-0.48) 1.31 (0.74-2.32) 0.206 CT+TT (134) 0.37 (0.25-0.51) rs11264580 TT (129) 0.37 (0.24-0.52) 0.77 (0.43-1.36) 0.263 TC+CC (163) 0.34 (0.22-0.47) rs11264581 GG (101) 0.34 (0.22-0.46) 2.06 (0.92-4.61) 0.278 GA+AA (191) 0.35 (0.24-0.52) rs12041331 GG (116) 0.35 (0.24-0.45) 1.32 (0.70-2.47) 0.718 GA+AA (176) 0.34 (0.23-0.53) rs12137505 GG (91) 0.38 (0.23-0.52) 0.92 (0.51-1.65) 0.765 GA+AA (201) 0.34 (0.23-0.48) rs12566888 GG (111) 0.35 (0.23-0.44) 1.32 (0.70-2.49) 0.502 GT+TT (181) 0.35 (0.23-0.53) rs2644592 AA (105) 0.37 (0.24-0.52) 0.96 (0.54-1.70) 0.364 AG+GG (187) 0.34 (0.22-0.48) rs2768759 AA (255) 0.34 (0.23-0.49) 1.74 (0.91-3.33) 0.115 AC+CC (37) 0.40 (0.30-0.52) rs3737224 CC (128) 0.37 (0.24-0.52) 0.76 (0.43-1.35) 0.279 CT+TT (164) 0.34 (0.22-0.47) rs41273215 CC (130) 0.37 (0.24-0.52) 0.67 (0.37-1.22) 0.194 CT+TT (162) 0.34 (0.22-0.46) rs4661012 GG (80) 0.39 (0.24-0.53) 0.78 (0.44-1.41) 0.261 GT+TT (212) 0.34 (0.22-0.48) rs56260937 CC (137) 0.39 (0.25-0.54) 0.48 (0.24-0.95) 0.030 CT+TT (155) 0.33 (0.22-0.46) rs57731889 CC (107) 0.35 (0.23-0.44) 1.92 (0.89-4.12) 0.567 CT+TT (185) 0.34 (0.23-0.52) rs822441 GG (109) 0.37 (0.24-0.49) 1.08 (0.60-1.96) 0.835 GC+CC (183) 0.34 (0.23-0.52) rs822442 CC (145) 0.39 (0.25-0.54) 0.51 (0.26-0.96) 0.031 CA+AA (147) 0.33 (0.22-0.43)