Comparison between sepsis-induced coagulopathy and sepsis-associated coagulopathy criteria in identifying sepsis-associated disseminated intravascular coagulation

Huixin Zhao, Yiming Dong, Sijia Wang, Jiayuan Shen, Zhenju Song, Mingming Xue, Mian Shao

Table 3. Comparison of SIC and SAC criteria for detecting overt-DIC in sepsis patients

Time SIC SAC P-value Day 1 Prevalence, % 22.0 (92/419) 31.5 (132/419) <0.001 AUC (95% CI) 0.85 (0.81-0.88) 0.83 (0.79-0.87) 0.307 Sensitivity, % 83.67 89.80 0.250 Specificity, % 86.22 76.22 <0.001 PPV, % 44.6 33.3 0.088 NPV, % 97.6 98.3 0.545 Day 3 Prevalence, % 14.1 (59/419) 20.8 (87/419) <0.001 AUC (95% CI) 0.84 (0.80-0.87) 0.81 (0.77-0.85) 0.097 Sensitivity, % 75.00 77.50 1.000 Specificity, % 92.16 84.86 <0.001 PPV, % 50.8 35.6 0.067 NPV, % 97.2 97.2 0.957 Day 7 Prevalence, % 10.3 (42/409) 14.4 (59/409) <0.001 AUC (95% CI) 0.86 (0.82-0.90) 0.89 (0.85-0.92) 0.422 Sensitivity, % 80.00 90.00 0.500 Specificity, % 92.40 88.18 <0.001 PPV, % 38.1 30.5 0.426 NPV, % 98.7 99.4 0.725 Day 14 Prevalence, % 5.7 (22/389) 7.5 (29/389) 0.016 AUC (95% CI) 0.93 (0.89-0.96) 0.91 (0.87-0.95) 0.007 Sensitivity, % 90.91 90.91 1.000 Specificity, % 94.69 91.59 0.016 PPV, % 45.5 34.5 0.128 NPV, % 99.5 99.5 0.539