| D0 (ICU admission) | No shivering | 37.1 | 45 | 1,591 | Propofol+remifentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 100%, PEEP: 5 cmH2O, SpO2 ≥94% | 40 mg iv. Q6h (1 iv) | 40 |
| D1 | 5 times, continued for 1 min per time | 37.7 | 43 | 6,450 | Propofol+remifentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 40%, PEEP: 5 cmH2O, SpO2 ≥94% | 40 mg iv. Q6h (4 iv) & 40 mg bolus | 200 |
| D2 | 5 times, continued for 1 min, 1 min, 2 min, 1 min, and 10 min, respectively | 39.5 | 54 | 8,310 | Midazolam+remifentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 40%, PEEP: 5 cmH2O, SpO2 ≥94% | 40 mg iv. Q6h (4 iv) | 160 |
| D3 | 2 times, continued for 10 min, and 30 min, respectively | 38.5 | 56 | 8,060 | Midazolam+remifentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 40%, PEEP: 8 cmH2O, SpO2 ≥94% | 40 mg bolus (2 iv) & 40 mg iv. Q6h (3 iv) | 200 |
| D4 | 4 times, continued for 30 min, 30 min, 30 min, and 50 min, respectively | 38.0 | 58 | 4,210 | Propofol+midazolam+remifentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 40%, PEEP: 8 cmH2O, SpO2 ≥94% | 60 mg iv. Q6h (4 iv) & 60 mg bolus | 300 |
| D5 | 1 time, continued for 15 min | 38.8 | 55 | 3,500 | Propofol+midazolam+sufentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 40%, PEEP: 8 cmH2O, SpO2 ≥94% | 60 mg iv. Q6h (4 iv) | 240 |
| D6 | 4 times, continued for 5 min, 6 min, 5 min, and 5 min, respectively | 38.6 | 51 | 2,700 | Propofol+midazolam+sufentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 40%, PEEP: 8 cmH2O, SpO2 ≥94% | 60 mg iv. Q6h (3 iv) & iv.vp. 10 mg/h for 3 h | 210 |
| D7 | 5 times, continued for 7 min, 20 min, 10 min, 10 min, and 12 min respectively | 38.9 | 56 | 2,700 | Propofol+midazolam+sufentanil
RASS score: -4 to -2 | Mechanical ventilation with FiO2: 40%, PEEP: 8 cmH2O, SpO2 ≥94% | iv.vp. 10 mg/h for 7 h & 60 mg iv. Q6h (4 iv) | 310 |
| D8 | 3 times, continued for 12 min, 6 min, and 8 min, respectively | 38.0 | 53 | 12,330 | Desist from sedation | Removal of endotracheal intubation & high-flow oxygen therapy (flow rate 35 L/min, oxygen concentration 40%, SpO2 ≥94%) | 60 mg iv. Q6h (4 iv) | 240 |
| D9 | Persistent weak shivering for 120 min | 39.3 | - | 12,800 | - | High-flow oxygen therapy (flow rate 35L/min, oxygen concentration 50%-100%, SpO2 ≥94%) | 60 mg iv. Q6h (4 iv) | 240 |
| D10 | Shivering for 10 min, persistent weak shivering for hours | 38.9 | - | 8,020 | - | Sat beside the bed (for rehabilitation exercise) for 30 min in the late morning with nasal catheter oxygen inhalation 5 L /min, SpO2 91%-95%, and continued to tremble in the afternoon, then high-flow oxygen therapy (flow rate 25 L/min, oxygen concentration 50%-55%, SpO2 ≥94%) | 60 mg iv. Q6h (2 iv) & 40 mg iv. Q6h (2 iv) | 200 |
| D11 | No shivering | 37.7 | - | 3,700 | - | Nasal catheter oxygen inhalation 5 L /min, SPO2 ≥94% | 60 mg bolus & 40 mg bolus then stop dosing | 100 |
| D12 | No shivering | 37.3 | - | - | - | Nasal catheter oxygen inhalation 5 L/min, SpO2 ≥94% | - | 0 |
| D13 | No shivering | 36.9 | - | - | - | Nasal catheter oxygen inhalation 5 L/min, SpO2 ≥94% | - | 0 |
| D14 (left ICU) | Weak shivering (head and limbs) improved automatically in a few minutes | 37.4 | - | - | - | Nasal catheter oxygen inhalation 5 L/min, SpO2 ≥94%
Transfered to orthopedic ward | - | 0 |
| D15-D35 | No shivering | <37.5 | - | D15 (920) D19 (645) | | Nasal catheter oxygen inhalation 3 L/min, SpO2 ≥94% (D15); no oxygen inhalation (D16-D35) | - | 0 |