Effects of mesencephalic astrocyte-derived neurotrophic factor on sepsis-associated acute kidney injury

Saifeng Chen, Xuewei Hao, Guo Chen, Guorong Liu, Xiaoyan Yuan, Peiling Shen, Dongfeng Guo

Figure 2. Changes of pro-inflammatory cytokines,BUN, SCr, and histological findings among different groups. A: changes of TNF-α; B: changes of IL-1β; C: changes of BUN; D: changes of SCr; E: histological findings of the kidney tissue detected by hematoxylin-eosin staining (H&E, ×40) staining. TNF-α: necrosis factor-α; IL-1β: interleukin-1β; MANF: mesencephalic astrocyte-derived neurotrophic factor; S-AKI: sepsis-associated acute kidney injury; BUN: blood urea nitrogen; SCr: serum creatinine. *P<0.05, **P<0.01, ***P<0.001