Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study

Jia-bao Li, Miao-rong Xie, Mei-li Duan, Ya-nan Yu, Chen-chen Hang, Zi-ren Tang, Chun-sheng Li

Table 2. Baseline characteristics of subgroups of sepsis patients on admission

Characteristics Sepsis (n=121) Septic shock (n=77) P-value Age, years 72 (55-82) 70 (56-79) 0.412 Male/Female 71/50 40/37 0.232 White blood cell count, ×109 13.02 (9.02-18.68) 11.74 (7.59-23.79) 0.640 Neutrophil percentage, % 87.90 (81.95-91.50) 90.30 (81.55-94.05) 0.087 Neutrophil count, ×109 11.80 (7.87-16.93) 11.41 (6.54-20.90) 0.915 Lymphocyte percentage, % 6.40 (3.45-11.05) 5.00 (3.15-12.70) 0.384 Lymphocyte count, ×109 0.82 (0.52-1.20) 0.65 (0.39-1.09) 0.236 Monocyte count, ×109 0.67 (0.38-1.00) 0.45 (0.19-0.74) 0.004 Lactate, mmol/L 1.60 (1.15-2.25) 2.90 (1.72-6.70) <0.001 SOFA score 5 (3-7) 10 (8-12) <0.001 APACHE Ⅱ score 13 (8-17) 19 (14-26) <0.001 28-day mortality 30 (24.8) 40 (51.9) <0.001 Comorbidity more than one 78 (64.5) 62 (80.5) 0.853 Primary infection sites Respiratory infection 68 (56.2) 37 (48.1) 0.263 Intra-abdominal infection 27 (22.3) 20 (26.0) 0.555 Cerebral infection 12 (9.9) 7 (9.1) 0.847 Urinary infection 11 (9.1) 11 (14.3) 0.257 Others 3 (2.5) 2 (2.6) 0.959