Over-expression of programmed death-ligand 1 and programmed death-1 on antigen-presenting cells as a predictor of organ dysfunction and mortality during early sepsis: a prospective cohort study

Jia-bao Li, Miao-rong Xie, Mei-li Duan, Ya-nan Yu, Chen-chen Hang, Zi-ren Tang, Chun-sheng Li

Table 1. Baseline characteristics of the participants

Characteristics Healthy control (n=40) Overall sepsis (n=198) P-value (control vs. overall) Age, years 68 (57-74) 71 (56-80) 0.389 Male/Female 20/20 111/87 0.121 White blood cell count, ×109 5.81 (4.85-6.52) 12.83 (8.00-19.28) <0.001 Neutrophil percentage, % 56.25 (48.03-63.33) 88.55 (81.98-92.75) <0.001 Neutrophil count, ×109 4.70 (3.62-5.65) 11.59 (7.08-17.69) <0.001 Lymphocyte percentage, % 2.30 (1.70-2.70) 6.10 (3.30-11.13) <0.001 Lymphocyte count, ×109 2.12 (1.74-2.36) 0.77 (0.48-1.14) <0.001 Monocyte count, ×109 0.29 (0.27-0.38) 0.56 (0.28-0.98) <0.001 Lactate, mmol/L 1.00 (0.60-1.38) 1.95 (1.30-3.23) <0.001 SOFA score 0 (0-1) 7 (4-10) <0.001 APACHE Ⅱ score 1 (0-2) 15 (10-21) <0.001 Comorbidity more than one 0 140 (70.7) <0.001 Primary infection sites Respiratory infection 105 (53.0) - Intra-abdominal infection 47 (23.7) - Cerebral infection 19 (9.6) - Urinary infection 22 (11.1) - Others 5 (2.5) -