Trichostatin A improves the inflammatory response and liver injury in septic mice through the FoxO3a/autophagy signaling pathway

Mei-jia Shen, Li-chao Sun, Xiao-yu Liu, Meng-chen Xiong, Shan Li, A-ling Tang, Guo-qiang Zhang

Table 1. Comparison of ALT, AST, IL-6, TNF-α in the serum and LC3 II, P62, and FoxO3a in the liver tissue at 12 h after the intervention in Institute of Cancer Research (ICR) mice

Parameters Control group TSA group CLP group CLP+TSA group ALT a, U/L 54.92±9.68 34.36±12.90 198.18±27.07** 128.42±20.55# AST a, U/L 206.05±17.11 100.49±6.39** 634.98±74.10** 478.60±32.56# IL-6 a, pg/mL 371.62±27.69 306.04±13.05** 2,665.27±324.90** 2,080.26±373.66# TNF-α a, pg/mL 177.79±24.72 135.00±17.40* 399.01±60.98** 221.90±46.89## LC3 II b 1 1.46±0.02** 1.36±0.01** 1.66±0.04## P62 b 1 0.60±0.02** 0.87±0.02** 0.59±0.02## FoxO3a b 1 2.03±0.13** 1.49±0.02** 2.89±0.03##