Speckle-tracking echocardiography for detecting myocardial dysfunction in sepsis and septic shock patients: A single emergency department study

Xuan Fu, Xue Lin, Samuel Seery, Li-na Zhao, Hua-dong Zhu, Jun Xu, Xue-zhong Yu

Table 1. Two-dimensional echocardiographic parameters and laboratory tests of the investigated groups

Variables	Sepsis 3.0			cTnI (99^th URL) 0.056 μg/L			LVEF_SB
Variables	Septic shock (n=21)	Sepsis (n=39)	P	≥99^th URL (n=23)	<99^th URL (n=37)	P	<50% (n=14)	≥50% (n=46)	P
Conventional echocardiography
LVEF_Teich, %	61.45±11.55	62.53±7.43	0.70	58.97±9.45	64.09±8.28	0.03^*	54.49±9.50	64.45±7.55	0.01^*
LVEF_SB, %	53.42±6.96	55.04±6.19	0.36	51.71±7.59	56.17±5.06	0.01^*	45.79±3.82	57.10±4.49	0.01^*
CI, %	29.88±16.59	28.81±12.76	0.77	28.39±14.46	29.68±14.09	0.73	0.27±0.16	0.30±0.13	0.49
LVOT_VTI, mm	16.52±3.94	17.22±3.59	0.50	15.74±3.80	17.74±3.46	0.04^*	14.63±3.72	17.69±3.41	0.01^*
LVOT_SV, mL	39.34±11.69	44.51±10.26	0.08	38.87±11.05	45.08±10.34	0.03^*	40.38±13.50	43.40±10.13	0.37
LVOT_CO, L/min	3.83±1.42	3.85±1.24	0.93	3.83±1.49	3.78±1.15	0.92	3.74±1.40	3.82±1.26	0.83
E/A	1.01±0.26	1.07±0.35	0.33	1 (0.90, 1.18)	1 (0.94, 1.17)	0.58	1 (1.00, 1.55)	1 (0.91, 1.14)	0.26
e', cm/s	12.48±3.84	12.12±3.04	0.69	12.23±3.51	12.23±3.20	0.95	12.55±4.20	12.13±3.01	0.68
E/e' ratio (lateral)	6.33±2.19	6.02±2.07	0.59	6.13±2.42	6.07±1.88	0.77	5.89±2.32	6.16±2.03	0.68
Speckle-tracking echocardiography
GLS, %	-15.48±3.43	-16.59±3.82	0.27	-14.74±4.21	-17.11±3.06	0.02^*	-12.29±2.61	-17.39±3.12	0.01^*
GCS, %	-17.19±4.77	-16.38±4.17	0.50	-15.17±4.31	-17.59±4.19	0.04^*	-14.14±4.00	-17.43±4.22	0.01^*
GRS, %	22.81±5.68	19.87±5.56	0.06	19.35±5.89	21.86±5.49	0.09	18.79±5.40	21.54±5.73	0.12
LVEF_STI, %	49.00±10.81	50.78±9.59	0.52	46.61±11.37	52.36±8.43	0.03^*	38.31±8.25	53.76±7.34	0.01^*
Laboratory test
Platelet, ×10⁹/L	186.05±96.42	178.85±100.07	0.79	149.61±88.79	201.11±99.47	0.05	132.00±86.25	196.39±97.30	0.03^*
CRP, mg/L	127.48±89.94	152.93±81.46	0.64	150.67±82.50	160.19±80.60	0.66	171.75±87.04	151.91±79.18	0.43
Procalcitonin, ng/L	4.65 (0.58, 16.50)	6.00 (1.00, 16.00)	0.17	10.00 (2.90, 74.00)	5.30 (1.40, 18.00)	0.04^*	10.00 (5.25, 91.00)	5.20 (1.30, 17.00)	0.14
cTnI, ng/mL	0.03 (0, 0.68)	0.02 (0, 0.02)	0.23	0 (0, 3.00)	0.02 (0, 0.02)	0.01^*	0.02 (0, 3.25)	0.02 (0, 0.02)	0.16
NT-proBNP, ng/mL	2989 (1002, 9663)	1031 (165, 5423)	0.02^*	6436 (2763, 17254)	881 (200, 1596)	0.01^*	12026 (4929, 18810)	1028 (246, 2832)	0.01^*
CK, U/L	108 (68, 391)	72 (34, 271)	0.31	180 (74, 414)	63 (32, 136)	0.30	233 (61, 945)	75 (35, 248)	0.11
CK-MB, U/L	1.8 (0.8, 5.7)	1.0 (0, 2.0)	0.05	2.0 (1.0, 9.0)	1.0 (0, 2.0)	0.10	2.0 (1.0, 18.0)	1.0 (0, 2.1)	0.02^*
Cr, μmol/L	156 (106, 224)	87 (59, 139)	0.01^*	136 (94, 209)	95 (58, 150)	0.05	159 (82, 232)	103 (63, 146)	0.09
Lac, mmol/L	3.3 (2.2,5.4)	2.0 (1.0, 2.0)	0.01^*	2.0 (2.0, 4.0)	2.0 (1.0, 3.0)	0.29	2.5 (2.0, 5.3)	2.0 (1.0, 3.0)	0.09