Protective effect of mesenchymal stem cell-derived exosomal treatment of hippocampal neurons against oxygen-glucose deprivation/reperfusion-induced injury

Xiao-fang Guo, Shuang-shuang Gu, Jun Wang, Hao Sun, Yu-juan Zhang, Peng-fei Yu, Jin-song Zhang, Lei Jiang

Table 1 The comparison between groups

Variables Control group OGD/R group OGD/R+Exo group Cell apoptosis 1.00±0.05 2.61±0.16** 1.15±0.29## ROS 1.00±0.30 1.64±0.47* 1.16±0.68# Cell viability 1.00±0.10 0.69±0.06* 0.80±0.10# Nrf2 accumulation 1.00±0.40 5.48±1.09** 2.14±0.65## SOD (U/mg) 22.86±1.13 14.40±0.62* 17.18±0.97# GPx (U/mg) 30.43±3.73 16.44±2.05* 20.65±2.23# Mitochondrial polarization to depolarization 1.00±0.13 0.40±0.07** 0.86±0.17 # DJ1 1.00±0.11 0.72±0.10* 1.09±0.05# OPA1 1.00±0.20 0.14±0.01** 0.52±0.08## Mfn-1 1.00±0.06 0.79±0.08** 1.04±0.02## Mfn-2 1.00±0.48 0.73±0.42** 1.07±0.11## LRRK2 1.00±0.09 39.02±2.64** 9.03±0.84## PINK 1.00±0.11 1.34±0.14* 0.10±0.01##