Prognosis-related classification and dynamic monitoring of immune status in patients with sepsis: A prospective observational study

Jun Yin, Yao Chen, Jun-ling Huang, Lei Yan, Zhong-shu Kuang, Ming-ming Xue, Si Sun, Hao Xiang, Yan-yan Hu, Zhi-min Dong, Chao-yang Tong, Chun-xue Bai, Zhen-ju Song

Figure 2. Kaplan-Meier survival curves of septic patients. A: comparison between the group with positive IL-10 levels and that with negative levels at day 3 (P<0.001); B: comparison between the group with positive HLA-DR levels and that with negative levels at day 3 (P<0.001); C: comparison between different immune status classifications at day 3 (SIRS vs. CARS [P<0.001], SIRS vs. MARS [P<0.001], CARS vs. MARS [P=0.008]); D: comparison between different classifications of immune status changes (SB vs. RM [P=0.028], SB vs. NR [P<0.001], SB vs. DT [P<0.001]). The survival curve of DT intersected with that of RM and NR, in which case the log-rank test was not conducted; HLA-DR: human leukocyte antigen-D-related; SIRS: systemic inflammatory response syndrome; CARS: compensatory anti-inflammatory response syndrome; MARS: mixed antagonistic response syndrome; DT: deterioration; NR: nonremission; RM: remission; SB: stabilization.