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Jun Yin, Yao Chen, Jun-ling Huang, Lei Yan, Zhong-shu Kuang, Ming-ming Xue, Si Sun, Hao Xiang, Yan-yan Hu, Zhi-min Dong, Chao-yang Tong, Chun-xue Bai, Zhen-ju Song
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| Parameters | Survivors (n=124) | Non-survivors (n=50) | P-value | | Age, years | 67.5 (48.3-78.0) | 67.0 (56.8-73.3) | 0.703 | | Male, n (%) | 78 (62.9) | 31 (62.0) | 0.911 | | Comorbidities, n (%) | | | | | Hypertension | 58 (46.8) | 25 (50.0) | 0.700 | | Diabetes mellitus | 33 (26.6) | 15 (30.0) | 0.651 | | Coronary heart disease | 12 (9.7) | 7 (14.0) | 0.408 | | Chronic obstructive pulmonary disease | 10 (8.1) | 5 (10.0) | 0.910 | | Hepatitis and cirrhosis | 12 (9.7) | 3 (6.0) | 0.595 | | Renal insufficiency | 14 (11.3) | 7 (14.0) | 0.620 | | Malignancy | 11 (8.9) | 6 (12.0) | 0.729 | | Main site of infection, n (%) | | | | | Respiratory tract | 80 (64.5) | 37 (74.0) | 0.707 | | Abdomen | 30 (24.2) | 8 (16.0) | 0.311 | | Urinary tract | 6 (4.8) | 2 (4.0) | 1.000 | | Skin and soft tissue | 4 (3.2) | 2 (4.0) | 1.000 | | Blood stream | 4 (3.2) | 1 (2.0) | 1.000 | | Index of severity of disease, median (25th, 75th) | | | | APACHE II score | | | | | Day 1 | 12 (7, 16) | 21 (12, 26) | <0.001 | | Day 3a | 9 (6, 13) | 18 (14, 25) | <0.001 | | SOFA score | | | | | Day 1 | 3 (2, 4) | 5 (4, 10) | <0.001 | | Day 3a | 2 (1, 4) | 6 (4, 8) | <0.001 | | Inflammatory markers, median (25th, 75th) | | | | WBC, ×109/L | | | | | Day 1 | 10.85 (6.99, 14.50) | 12.60 (8.16, 18.40) | 0.024 | | Day 3a | 9.07 (6.90, 12.09) | 13.15 (9.55, 19.79) | <0.001 | | CRP, mg/L | | | | | Day 1 | 90 (57, 96) | 90 (63, 139) | 0.353 | | Day 3a | 52 (15, 105) | 90 (66, 144) | 0.002 | | PCT, ng/L | | | | | Day 1 | 1.14 (0.29, 5.07) | 1.47 (0.40, 10.40) | 0.172 | | Day 3a | 0.56 (0.15, 1.98) | 1.85 (0.60, 11.13) | <0.001 | | Interventions, n (%) | | | | | Glucocorticoids (prednisone >200 mg) | 67 (54.0) | 38 (76.0) | 0.007 | | Mechanical ventilation | 62 (50.0) | 46 (92.0) | <0.001 | | Deep venous catheterization | 54 (43.5) | 38 (76.0) | <0.001 | | Urinary catheterization | 57 (46.0) | 43 (86.0) | <0.001 | | Adverse events, n (%) | | | | | Septic shock | 16 (12.9) | 20 (40.0) | <0.001 | | Secondary infection | 36 (29.0) | 14 (28.0) | 0.019 | | Acute heart failure | 26 (20.9) | 22 (44.0) | 0.002 | | Acute kidney injury | 21 (16.9) | 19 (38.0) | 0.003 | | Acute liver injury | 14 (11.3) | 16 (32.0) | <0.001 | | Acute respiratory failure | 37 (29.8) | 28 (56.0) | <0.001 | | ICU length of stay (days) | 14.0 (10.0, 21.8) | 10.0 (5.0, 20.5) | <0.002 |
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