Effects of extracellular vesicles from mesenchymal stem cells on oxygen-glucose deprivation/reperfusion-induced neuronal injury

Shuang-shuang Gu, Xiu-wen Kang, Jun Wang, Xiao-fang Guo, Hao Sun, Lei Jiang, Jin-song Zhang

Figure 2. Effects of BMSC-sEVs on OGD/R-induced neuronal injury and oxidative stress. A: cell viability measured by cell counting kit-8 assay; B: cytotoxicity assessed by lactate dehydrogenase (LDH) assay; C, D, E, and F: levels of oxidative status markers including mitochondrial membrane potential (MMP), reactive oxygen species (ROS) generation, glutathione peroxidase (GPx), and superoxide dismutase (SOD) determined using respective assay kits; BMSCs: bone marrow mesenchymal stem cells; sEVs: small extracellular vesicles; OGD/R: oxygen-glucose deprivation and reperfusion; compared with the control group, ##P<0.01; compared with the OGD/R group, *P<0.05, **P<0.01.