MicroRNA-145 plays a role in mitochondrial dysfunction in alveolar epithelial cells in lipopolysaccharide-induced acute respiratory distress syndrome
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MicroRNA-145 plays a role in mitochondrial dysfunction in alveolar epithelial cells in lipopolysaccharide-induced acute respiratory distress syndrome |
| Yi Han, Su-cheng Mu, Jian-li Wang, Wei Wei, Ming Zhu, Shi-lin Du, Min Min, Yun-jie Xu, Zhen-ju Song, Chao-yang Tong |
| Figure 3. Bioinformatics data of microRNA-145 target genes and pathways. Compared with control, *P<0.05; A: target genes of microRNA-145 predicted using TargetScan and miRDB tools; B: KEGG pathway analysis (Y-axis representing the enriched KEGG terms, X-axis representing the amount of the microRNA-145-related mRNAs enriched in KEGG terms); C: GO biological process (Y-axis representing the enriched GO terms, X-axis representing the amount of the microRNA-145-related mRNAs enriched in GO terms); D: Ogt, Camk2d, Scl8a3, and Scl25a25 mRNAs were slightly up-regulated at 24 hours post LPS instillation, while significantly down-regulated at 72 hours post LPS instillation; MAPK: mitogen-activated protein kinase; KEGG: Kyoto Encyclopedia of Genes and Genomes; GO: Gene Ontology; LPS: lipopolysaccharide. |
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