Coronavirus disease 2019 (COVID-19) and prosthetic heart valve: An additional coagulative challenge

Attilio Allione, Jacopo Davide Giamello, Sara Bernardi, Giulia Paglietta, Giulia Lucia Massimina Cavalot, Luca Alessio Dutto, Daniela Caruso, Andrea Tortore, Giuseppe Lauria

Table 1 Laboratory data

Variables Reference range Admission (hospital day 0) (on warfarin) Initial improvement (hospital day 2) Deterioration and EP diagnosis (hospital day 5) Improvement (hospital day 8) (heparin day 3) White blood cell (cells/μL) 4,000-10,800 12,300 11,400 10,150 8,886 Lymphocytes (cells/μL) 1,200-4,000 510 710 530 780 C-reactive protein (mg/dL) <5.0 257.6 301.5 215.4 118.6 Procalctitonin (ng/mL) <0.1 1.1 2.8 2.0 0.2 Lactate dehydrogenase (U/L) 120-250 458 435 525 361 Platelets (cells/μL) 130,000-424,000 275,000 437,000 276,000 337,000 International normalized ratio 0.80-1.20 7.48 5.86 3.07 2.80 aPTT ratio 0.80-1.20 1.98 0.88 1.57 1.66 D-dimer (μg/mL) <0.50 1.16 1.45 128.66 5.13 Antithrombin III (%) 80-120 103 107 88 90 Fibrinogen (mg/dL) 150-450 1,012 814 549 593 Troponin I (pg/mL) <57.3 21.9 14.0 6,338.4 2,749.7 NT-pro-BPN (pg/mL) <450 5,973 6,585 12,819 6,750