World Journal of Emergency Medicine ›› 2020, Vol. 11 ›› Issue (4): 216-222.doi: 10.5847/wjem.j.1920-8642.2020.04.003
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Yu-ming Wang1, Yan-jun Zheng1, Ying Chen1, Yun-chuan Huang1, Wei-wei Chen1, Ran Ji1, Li-li Xu1, Zhi-tao Yang1, Hui-qiu Sheng1, Hong-ping Qu2, En-qiang Mao1(
), Er-zhen Chen1()
Received:2019-11-01
Accepted:2020-05-20
Online:2020-10-01
Published:2020-10-01
Contact:
En-qiang Mao,Er-zhen Chen
E-mail:maoeq@yeah.net;chenerzhen@hotmail.com
Yu-ming Wang, Yan-jun Zheng, Ying Chen, Yun-chuan Huang, Wei-wei Chen, Ran Ji, Li-li Xu, Zhi-tao Yang, Hui-qiu Sheng, Hong-ping Qu, En-qiang Mao, Er-zhen Chen. Effects of fluid balance on prognosis of acute respiratory distress syndrome patients secondary to sepsis[J]. World Journal of Emergency Medicine, 2020, 11(4): 216-222.
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URL: http://wjem.com.cn/EN/10.5847/wjem.j.1920-8642.2020.04.003
Figure 1.
Study flow chart.
Table 1
Characteristics of sepsis patients with or without ARDS
| Parameters | Patients (n=322) | No ARDS (n=238) | ARDS (n=84) | P-value |
|---|---|---|---|---|
| Sex Male Female Age (years) BMI (kg/m2) Sepsis category Septic shock Sepsis Mortality Origin EICU Medical emergency ward Trauma surgery ward Other Comorbidities Hypertension Diabetes Arrhythmia CHD CKD Cerebral infarction Source of sepsis Gut Lung Urinary tract Abdomen Skin Blood Not found Other SOFA score APACHE II Creatinine (μmol/L) PaO2/FiO2 (mmHg) Duration of hospital stay (days) Duration of ICU stay (days) Duration of mechanical ventilation (days) | 195 (60.6) 127 (39.4) 62 (46-73) 23.68±3.80 192 (59.6) 130 (40.4) 72 (22.4) 219 (68.0) 67 (20.8) 9 (2.8) 27 (8.4) 138 (42.9) 78 (24.2) 19 (5.9) 26 (8.1) 5 (1.6) 12 (3.7) 35 (10.9) 181 (56.2) 18 (5.6) 48 (14.9) 9 (2.8) 8 (2.5) 13 (4.0) 10 (3.1) 6 (4-8) 11±5 167.4±217.3 231.9±94.8 21 (13-34) 14 (7-25) 0 (0-8) | 142 (59.7) 96 (40.3) 63 (43-73) 23.65±3.81 139 (58.4) 99 (41.6) 37 (15.5) 156 (65.5) 58 (24.4) 6 (2.5) 18 (7.6) 95 (39.9) 52 (21.8) 13 (5.5) 20 (8.4) 8 (3.4) 4 (1.7) 28 (11.8) 120 (50.4) 18 (7.6) 39 (16.3) 9 (3.8) 6 (2.5) 10 (4.2) 8 (3.4) 5 (3-7) 10±5 163.3±223.5 255.0±91.2 21 (14-33) 14 (7-24) 0 (0-0) | 53 (63.1) 31 (36.9) 62 (50-70) 23.71±3.83 53 (63.1) 31 (36.9) 35 (41.7) 63 (75.0) 9 (10.7) 3 (3.6) 9 (10.7) 43 (51.2) 26 (31.0) 6 (7.1) 6 (7.1) 4 (4.8) 1 (1.2) 7 (8.3) 61 (72.6) 0 (0) 9 (10.7) 0 (0) 2 (2.4) 3 (3.6) 2 (2.4) 8 (4-8) 14±5 178.8±198.7 166.4±71.0 23 (11-45) 15 (7-31) 11 (6-24) | 0.580 0.900 0.892 0.451 <0.001 0.110 0.008 0.907 0.370 0.322 0.094 0.574 0.715 0.804 1.000 0.385 <0.001 0.001 0.210 0.019 1.000 1.000 0.937 <0.001 <0.001 0.582 <0.001 0.737 0.227 <0.001 |
Table 2
Characteristics of survivors and non-survivors
| Parameters | Survivors (n=49) | Non-survivors (n=35) | P-value |
|---|---|---|---|
| Sex Male Female Age (years) BMI (kg/m2) Sepsis category Septic shock Sepsis Origin EICU Medical emergency ward Trauma surgery ward Other Comorbidities Hypertension Diabetes Arrhythmia CHD CKD Cerebral infarction Source of sepsis Gut Lung Abdomen Other Not found SOFA score APACHE II score PEEP (cmH2O) Tidal volume (mL/kg) PaO2/FiO2 (mmHg) Creatinine (μmol/L) Duration of hospital stay (days) Duration of ICU stay (days) Duration of mechanical ventilation (days) | 32 (65.3) 17 (34.7) 64 (51-70) 24.30±3.50 29 (59.2) 20 (40.8) 33 (67.3) 7 (14.3) 3 (6.1) 6 (12.3) 29 (59.2) 15 (30.6) 4 (8.2) 6 (12.2) 4 (8.2) 1 (2.0) 5 (10.2) 37 (75.5) 4 (8.2) 1 (2.0) 2 (4.1) 7 (6-9) 13±5 6 (5-8) 8.6±2.1 175.1±71.5 148.2±161.3 32 (18-66) 19 (7-31) 12 (7-25) | 21 (60.0) 14 (40.0) 57 (44-70) 22.89±4.10 24 (68.6) 11 (31.4) 30 (85.7) 2 (5.7) 0 (0) 3 (8.6) 14 (40.0) 11 (31.4) 2 (5.7) 0 (0) 1 (2.9) 0 (0) 2 (5.7) 24 (68.6) 5 (14.3) 3 (8.6) 1 (2.9) 8 (7-11) 16±5 5 (5-8) 8.0±2.6 154.1±68.4 223.5±233.2 12 (7-25) 10 (7-18) 7 (6-18) | 0.619 0.427 0.097 0.379 0.055 0.371 0.069 0.858 0.083 0.936 1.000 0.009 0.585 0.297 0.739 0.482 0.592 0.386 1.000 0.022 0.023 0.233 0.312 0.186 0.089 <0.001 0.001 0.300 |
Figure 2.
Mean fluid balance (mL/kg, mean±standard deviation) in sepsis patients with or without ARDS during seven continuous days after onset of sepsis. *Statistically significant difference at the P<0.05 level between two groups.
Figure 3.
Mean fluid balance (mL/kg, mean±standard deviation) in survivors and non-survivors during seven continuous days in sepsis patients complicating with ARDS. *Statistically significant difference at the P<0.05 level between two groups. ns: not significant.
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